Literature DB >> 11816964

The tylosin-biosynthetic genes of Streptomyces fradiae.

E Cundliffe1, N Bate, A Butler, S Fish, A Gandecha, L Merson-Davies.   

Abstract

The tylosin-biosynthetic (tyl) gene cluster occupies about 1% of the genome of Streptomycesfradiae and includes at least 43 open reading frames. In addition to structural genes required for tylosin production, the tyl cluster contains three resistance determinants and several regulatory genes. Tylosin production is evidently controlled by pathway-specific and pleiotropic regulators with the likely involvement of y-butyrolactone signalling factors. Accumulation of the polyketide aglycone is controlled by glycosylated macrolides and optimal performance of the complex polyketide synthase enzyme requires the activity of an editing thioesterase.

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Year:  2001        PMID： 11816964     DOI： 10.1023/a:1012065300116

Source DB:  PubMed          Journal:  Antonie Van Leeuwenhoek        ISSN： 0003-6072            Impact factor:   2.271


  22 in total

1.  Molecular evidence for the ancient origin of the ribosomal protection protein that mediates tetracycline resistance in bacteria.

Authors:  Takeshi Kobayashi; Lisa Nonaka; Fumito Maruyama; Satoru Suzuki
Journal:  J Mol Evol       Date:  2007-08-04       Impact factor: 2.395

2.  Type I polyketide synthases may have evolved through horizontal gene transfer.

Authors:  Aurélien Ginolhac; Cyrille Jarrin; Patrick Robe; Guy Perrière; Timothy M Vogel; Pascal Simonet; Renaud Nalin
Journal:  J Mol Evol       Date:  2005-05-16       Impact factor: 2.395

3.  Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies.

Authors:  Charles E Melançon; Lin Hong; Jess A White; Yung-nan Liu; Hung-wen Liu
Journal:  Biochemistry       Date:  2007-01-16       Impact factor: 3.162

Review 4.  The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines.

Authors:  Adrian T Keatinge-Clay
Journal:  Chem Rev       Date:  2017-04-10       Impact factor: 60.622

5.  Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450.

Authors:  Matthew D DeMars; Nathan L Samora; Song Yang; Marc Garcia-Borràs; Jacob N Sanders; K N Houk; Larissa M Podust; David H Sherman
Journal:  J Biol Chem       Date:  2019-09-05       Impact factor: 5.157

6.  Regulation of the biosynthesis of the macrolide antibiotic spiramycin in Streptomyces ambofaciens.

Authors:  Fatma Karray; Emmanuelle Darbon; Hoang Chuong Nguyen; Josette Gagnat; Jean-Luc Pernodet
Journal:  J Bacteriol       Date:  2010-09-03       Impact factor: 3.490

7.  Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the duplicated type II polyketide synthase alp gene cluster in Streptomyces ambofaciens.

Authors:  Bertrand Aigle; Xiuhua Pang; Bernard Decaris; Pierre Leblond
Journal:  J Bacteriol       Date:  2005-04       Impact factor: 3.490

Review 8.  Natural-product sugar biosynthesis and enzymatic glycodiversification.

Authors:  Christopher J Thibodeaux; Charles E Melançon; Hung-wen Liu
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

9.  The influences of pH and ionic strength on the sorption of tylosin on goethite.

Authors:  Xuetao Guo; Chen Yang; Yinai Wu; Zhi Dang
Journal:  Environ Sci Pollut Res Int       Date:  2013-10-04       Impact factor: 4.223

10.  The crystal structure of the novobiocin biosynthetic enzyme NovP: the first representative structure for the TylF O-methyltransferase superfamily.

Authors:  Inmaculada Gómez García; Clare E M Stevenson; Isabel Usón; Caren L Freel Meyers; Christopher T Walsh; David M Lawson
Journal:  J Mol Biol       Date:  2009-10-24       Impact factor: 5.469
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