OBJECTIVE: Our purpose was to examine the relationship between physical activity (PA), PA-associated energy expenditure (PAEE), and total daily energy expenditure (TEE) in free-living adolescents with sickle-cell anemia (SCA). STUDY DESIGN: Adolescents with SCA (n = 28) were matched for sex and age with 22 healthy control participants. PA was measured for 6 to 8 consecutive days with a triaxial accelerometer and resting energy expenditure (REE) by whole-room indirect calorimetry. TEE was calculated by summing PAEE and REE. RESULTS: TEE was similar, REE was higher (difference, 209 kcal x day(-1); P =.0001), and PAEE was lower (difference, 657 kcal x day(-1); P <.001) in patients with SCA than in control participants. In SCA, there was a positive linear relationship between PAEE and hemoglobin concentration (r (2) = 0.583). Time spent in PA of moderate and high intensity was lower in patients with SCA than in control participants (18 +/- 22 vs 48 +/- 31 min/d; P <.0001). CONCLUSION: In adolescents with SCA under free-living conditions, there is a significant intra and interindividual variability in the amount of PA, PAEE, and PA patterns. Because of a lower PAEE and a higher REE, TEE is similar in adolescents with SCA and healthy adolescents. An association of PAEE with hemoglobin concentration may be a part of an energy saving compensatory mechanism in SCA.
OBJECTIVE: Our purpose was to examine the relationship between physical activity (PA), PA-associated energy expenditure (PAEE), and total daily energy expenditure (TEE) in free-living adolescents with sickle-cell anemia (SCA). STUDY DESIGN: Adolescents with SCA (n = 28) were matched for sex and age with 22 healthy control participants. PA was measured for 6 to 8 consecutive days with a triaxial accelerometer and resting energy expenditure (REE) by whole-room indirect calorimetry. TEE was calculated by summing PAEE and REE. RESULTS: TEE was similar, REE was higher (difference, 209 kcal x day(-1); P =.0001), and PAEE was lower (difference, 657 kcal x day(-1); P <.001) in patients with SCA than in control participants. In SCA, there was a positive linear relationship between PAEE and hemoglobin concentration (r (2) = 0.583). Time spent in PA of moderate and high intensity was lower in patients with SCA than in control participants (18 +/- 22 vs 48 +/- 31 min/d; P <.0001). CONCLUSION: In adolescents with SCA under free-living conditions, there is a significant intra and interindividual variability in the amount of PA, PAEE, and PA patterns. Because of a lower PAEE and a higher REE, TEE is similar in adolescents with SCA and healthy adolescents. An association of PAEE with hemoglobin concentration may be a part of an energy saving compensatory mechanism in SCA.
Authors: Andrew M Watson; Robert I Liem; Zengqi Lu; Ben Saville; Sari Acra; Sadhna Shankar; Maciej Buchowski Journal: Pediatr Blood Cancer Date: 2014-12-31 Impact factor: 3.167
Authors: Cindy A Dorminy; Leena Choi; Sylvie A Akohoue; Kong Y Chen; Maciej S Buchowski Journal: Med Sci Sports Exerc Date: 2008-04 Impact factor: 5.411
Authors: Melissa Rhodes; Sylvie A Akohoue; Sadhna M Shankar; Irma Fleming; Angel Qi An; Chung Yu; Sari Acra; Maciej S Buchowski Journal: Pediatr Blood Cancer Date: 2009-10 Impact factor: 3.167