Literature DB >> 11814827

N-arylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: phenylpropylamines as potential leads for selective sigma-2 agents.

Dean Y Maeda1, Wanda Williams, Wes E Kim, Linn N Thatcher, Wayne D Bowen, Andrew Coop.   

Abstract

To delineate the differences between the structural requirements necessary for recognition at sigma-1 and sigma-2 receptors, a range of phenethyl- and phenylpropylpiperidines were evaluated in binding assays. Phenethylpiperidines were found to favor sigma-1 receptors, whereas phenylpropylpiperidines tend to favor sigma-2 receptors. It appears that phenylpropylamine is a potential pharmacophore for selective sigma-2 ligands.

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Year:  2002        PMID： 11814827     DOI： 10.1016/s0960-894x(01)00788-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Effects of the selective sigma receptor ligand, 1-(2-phenethyl)piperidine oxalate (AC927), on the behavioral and toxic effects of cocaine.

Authors:  Rae R Matsumoto; Su-Min Li; Jonathan L Katz; William E Fantegrossi; Andrew Coop
Journal:  Drug Alcohol Depend       Date:  2011-03-21       Impact factor: 4.492

Review 2.  The ligand binding region of the sigma-1 receptor: studies utilizing photoaffinity probes, sphingosine and N-alkylamines.

Authors:  Arnold E Ruoho; Uyen B Chu; Subramaniam Ramachandran; Dominique Fontanilla; Timur Mavlyutov; Abdol R Hajipour
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

3.  The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands.

Authors:  Lidiya Stavitskaya; Michael J Seminerio; Marilyn M Matthews-Tsourounis; Rae R Matsumoto; Andrew Coop
Journal:  Bioorg Med Chem Lett       Date:  2010-03-01       Impact factor: 2.823

4.  Novel sigma (sigma) receptor agonists produce antidepressant-like effects in mice.

Authors:  Jiajia Wang; Aisha L Mack; Andrew Coop; Rae R Matsumoto
Journal:  Eur Neuropsychopharmacol       Date:  2007-03-21       Impact factor: 4.600

5.  Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands.

Authors:  Susan L Mercer; Jamaluddin Shaikh; John R Traynor; Rae R Matsumoto; Andrew Coop
Journal:  Eur J Med Chem       Date:  2007-10-06       Impact factor: 6.514

6.  Effects of UMB24 and (+/-)-SM 21, putative sigma2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in mice.

Authors:  Rae R Matsumoto; Buddy Pouw; Aisha L Mack; Antawan Daniels; Andrew Coop
Journal:  Pharmacol Biochem Behav       Date:  2006-12-22       Impact factor: 3.533

7.  AC927, a σ receptor ligand, blocks methamphetamine-induced release of dopamine and generation of reactive oxygen species in NG108-15 cells.

Authors:  Nidhi Kaushal; Meenal Elliott; Matthew J Robson; Anand Krishnan V Iyer; Yon Rojanasakul; Andrew Coop; Rae R Matsumoto
Journal:  Mol Pharmacol       Date:  2011-11-18       Impact factor: 4.436

8.  Sigma (σ) receptor ligand, AC927 (N-phenethylpiperidine oxalate), attenuates methamphetamine-induced hyperthermia and serotonin damage in mice.

Authors:  Michael J Seminerio; Nidhi Kaushal; Jamaluddin Shaikh; Jason D Huber; Andrew Coop; Rae R Matsumoto
Journal:  Pharmacol Biochem Behav       Date:  2010-12-02       Impact factor: 3.533

9.  Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands.

Authors:  William C Motel; Jason R Healy; Eddy Viard; Buddy Pouw; Kelly Martin; Rae R Matsumoto; Andrew Coop
Journal:  Bioorg Med Chem Lett       Date:  2013-10-15       Impact factor: 2.823

10.  Attenuation of methamphetamine-induced effects through the antagonism of sigma (sigma) receptors: Evidence from in vivo and in vitro studies.

Authors:  Rae R Matsumoto; Jamaluddin Shaikh; Lisa L Wilson; Shreedeepalakshmi Vedam; Andrew Coop
Journal:  Eur Neuropsychopharmacol       Date:  2008-08-27       Impact factor: 4.600
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