Literature DB >> 20338757

The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands.

Lidiya Stavitskaya1, Michael J Seminerio, Marilyn M Matthews-Tsourounis, Rae R Matsumoto, Andrew Coop.   

Abstract

A series of pyridylpiperazines was synthesized and analyzed for sigma receptor binding affinity to determine the optimal pyridyl nitrogen position and chain length for the sigma(1) and sigma(2) receptor recognition. The (3-pyridyl)piperazines and (4-pyridyl)piperazines favor sigma(1) receptors, while previously studied (2-pyridyl)piperazines favor sigma(2) receptors. Copyright 2010. Published by Elsevier Ltd.

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Year:  2010        PMID： 20338757      PMCID： PMC3401592          DOI： 10.1016/j.bmcl.2010.02.087

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  32 in total

1.  Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem.

Authors:  M P Morin-Surun; T Collin; M Denavit-Saubié; E E Baulieu; F P Monnet
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

2.  Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene.

Authors:  P D Prasad; H W Li; Y J Fei; M E Ganapathy; T Fujita; L H Plumley; T L Yang-Feng; F H Leibach; V Ganapathy
Journal:  J Neurochem       Date:  1998-02       Impact factor: 5.372

3.  Effects of UMB24 and (+/-)-SM 21, putative sigma2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in mice.

Authors:  Rae R Matsumoto; Buddy Pouw; Aisha L Mack; Antawan Daniels; Andrew Coop
Journal:  Pharmacol Biochem Behav       Date:  2006-12-22       Impact factor: 3.533

4.  Repeated methamphetamine-treatment alters brain sigma receptors.

Authors:  Y Itzhak
Journal:  Eur J Pharmacol       Date:  1993-01-12       Impact factor: 4.432

5.  Biochemical characterization of a 22-kDa high affinity antiischemic drug-binding polypeptide in the endoplasmic reticulum of guinea pig liver: potential common target for antiischemic drug action.

Authors:  F F Moebius; G G Burrows; J Striessnig; H Glossmann
Journal:  Mol Pharmacol       Date:  1993-02       Impact factor: 4.436

6.  Involvement of sigma (sigma) receptors in the acute actions of methamphetamine: receptor binding and behavioral studies.

Authors:  Emily C Nguyen; Kari A McCracken; Yun Liu; Buddy Pouw; Rae R Matsumoto
Journal:  Neuropharmacology       Date:  2005-10       Impact factor: 5.250

Review 7.  The role of sigma receptors in depression.

Authors:  Jordanna E Bermack; Guy Debonnel
Journal:  J Pharmacol Sci       Date:  2005-03-05       Impact factor: 3.337

8.  Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism.

Authors:  R R Matsumoto; W D Bowen; M A Tom; V N Vo; D D Truong; B R De Costa
Journal:  Eur J Pharmacol       Date:  1995-07-14       Impact factor: 4.432

9.  Stimulation of rat striatal tyrosine hydroxylase activity following intranigral administration of sigma receptor ligands.

Authors:  S D Weiser; S L Patrick; S W Mascarella; J Downing-Park; X Bai; F I Carroll; J M Walker; R L Patrick
Journal:  Eur J Pharmacol       Date:  1995-02-24       Impact factor: 4.432

10.  DTG-induced circling behaviour in rats may involve the interaction between sigma sites and nigro-striatal dopaminergic pathways.

Authors:  S Bastianetto; L Rouquier; G Perrault; D J Sanger
Journal:  Neuropharmacology       Date:  1995-03       Impact factor: 5.250
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  3 in total

1.  Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands.

Authors:  William C Motel; Jason R Healy; Eddy Viard; Buddy Pouw; Kelly Martin; Rae R Matsumoto; Andrew Coop
Journal:  Bioorg Med Chem Lett       Date:  2013-10-15       Impact factor: 2.823

Review 2.  The σ2 receptor: a novel protein for the imaging and treatment of cancer.

Authors:  Robert H Mach; Chenbo Zeng; William G Hawkins
Journal:  J Med Chem       Date:  2013-06-18       Impact factor: 7.446

3.  QSAR-Based Computational Approaches to Accelerate the Discovery of Sigma-2 Receptor (S2R) Ligands as Therapeutic Drugs.

Authors:  Yangxi Yu; Hiep Dong; Youyi Peng; William J Welsh
Journal:  Molecules       Date:  2021-08-30       Impact factor: 4.411
  3 in total

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