| Literature DB >> 1180964 |
A J Bailey, S Bazin, T J Sims, M Le Lous, C Nicoletis, A Delaunay.
Abstract
The collagen produced in response to an injury of human skin is initially stabilized by a cross-link derived from hydroxyallysine, and characteristic of embryonic skin. In normal healing there is a change over with time to the cross-link derived from allysine, which is typical of young skin collagen. In contrast, hypertrophic scars fail to follow the time-related changes of normal skin, but retain the characteristics of embryonic collagen, indicating a continued rapid turnover of the collagen. This is further supported by the high proportion of the embryonic Type III collagen present in hypertrophic scars.Entities:
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Year: 1975 PMID： 1180964 DOI： 10.1016/0005-2795(75)90106-3
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002