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Literature DB >> 118049

Silymarin, an inhibitor of prostaglandin synthetase.

Abstract

Silybin (I), silydianin (II) and silychristin (III), the main constituents of silymarin, inhibit the formation of prostaglandins in vitro. The inhibition is log-linearly dependent on the concentration of the effectors.

Entities: Chemical

Mesh：

Substances：

Year: 1979 PMID： 118049 DOI： 10.1007/bf01953185

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

17 in total

1. Colorimetric identification of prostaglandins in subnanomole amounts.

Authors: H C Kiefer; C R Johnson; K L Arora; H S Kantor
Journal: Anal Biochem Date: 1975-09 Impact factor: 3.365

2. [The chemistry and analysis of silymarin from Silybum marianum Gaertn].

Authors: H Wagner; P Diesel; M Seitz
Journal: Arzneimittelforschung Date: 1974-04

3. [Silymarin prevents peroxidation of lipids in carbon tetrachloride-induced liver damage].

Authors: H M Rauen; H Schriewer; U Tegtbauer; J E Lasana
Journal: Experientia Date: 1973-11-15

4. [On the pharmacology and toxicology of silymarin, an antihepatotoxic active principle from Silybum marianum (L.) Gaertn].

Authors: G Hahn; H D Lehmann; M Kürten; H Uebel; G Vogel
Journal: Arzneimittelforschung Date: 1968-06

5. Role of prostaglandin endoperoxide PGG2 in inflammatory processes.

Authors: F A Kuehl; J L Humes; R W Egan; E A Ham; G C Beveridge; C G Van Arman
Journal: Nature Date: 1977-01-13 Impact factor: 49.962

6. Relationship between lipid peroxidation and prostaglandin generation in rabbit tissues.

Authors: J Robak; B Sobańska
Journal: Biochem Pharmacol Date: 1976-10-15 Impact factor: 5.858

7. Properties of a partially-purified preparation of the prostaglandin-forming oxygenase from sheep vesicular gland.

Authors: L H Rome; M E Lands
Journal: Prostaglandins Date: 1975-11

Review 8. [The roll of prostaglandins and catecholamines in inflammation and in the mode of action of antiphlogistics].

Authors: H Bekemeier; A J Giessler; R Hirschelmann
Journal: Pharmazie Date: 1974 Oct-Nov Impact factor: 1.267

9. Oxygenation of unsaturated fatty acids by the vesicular gland of sheep.

Authors: M Hamberg; B Samuelsson
Journal: J Biol Chem Date: 1967-11-25 Impact factor: 5.157

Review 10. Prostaglandins as mediators of inflammation.

Authors: J R Vane
Journal: Adv Prostaglandin Thromboxane Res Date: 1976

4 in total

1. Silibinin (Legalon-70) enhances the motility of human neutrophils immobilized by formyl-tripeptide, calcium ionophore, lymphokine and by normal human serum.

Authors: L Kalmár; J Kádár; A Somogyi; P Gergely; G Csomós; J Fehér
Journal: Agents Actions Date: 1990-03