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Literature DB >> 11804581

The spliceosome: no assembly required?

Abstract

In this issue of Molecular Cell, Stevens et al. purify a large particle from yeast extracts that contains all five of the U snRNPs required for pre-mRNA splicing. The existence of this "penta-snRNP" suggests the provocative possibility that spliceosome assembly does not depend upon a pre-mRNA substrate.

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Year: 2002 PMID： 11804581 DOI： 10.1016/s1097-2765(02)00430-6

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

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Cited

28 in total

1. The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites.

Authors: Patrik Förch; Oscar Puig; Concepción Martínez; Bertrand Séraphin; Juan Valcárcel
Journal: EMBO J Date: 2002-12-16 Impact factor: 11.598

2. The U1 snRNP base pairs with the 5' splice site within a penta-snRNP complex.

Authors: Hadar Malca; Noam Shomron; Gil Ast
Journal: Mol Cell Biol Date: 2003-05 Impact factor: 4.272

3. Identification and characterization of Prp45p and Prp46p, essential pre-mRNA splicing factors.

Authors: Michael Albers; Ann Diment; Mariela Muraru; Caroline S Russell; Jean D Beggs
Journal: RNA Date: 2003-01 Impact factor: 4.942

4. Reversible inhibition of the second step of splicing suggests a possible role of zinc in the second step of splicing.

Authors: Noam Shomron; Hadar Malca; Ida Vig; Gil Ast
Journal: Nucleic Acids Res Date: 2002-10-01 Impact factor: 16.971

5. RBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP recruitment.

Authors: Shu-Ching Huang; Alexander C Ou; Jennie Park; Faye Yu; Brian Yu; Angela Lee; Guang Yang; Anyu Zhou; Edward J Benz
Journal: Mol Cell Biol Date: 2011-11-14 Impact factor: 4.272

6. Proximity of the U12 snRNA with both the 5' splice site and the branch point during early stages of spliceosome assembly.

Authors: Mikko J Frilander; Xiaojuan Meng
Journal: Mol Cell Biol Date: 2005-06 Impact factor: 4.272

The spliceosome: no assembly required?

1. The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites.

2. The U1 snRNP base pairs with the 5' splice site within a penta-snRNP complex.

3. Identification and characterization of Prp45p and Prp46p, essential pre-mRNA splicing factors.

4. Reversible inhibition of the second step of splicing suggests a possible role of zinc in the second step of splicing.

5. RBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP recruitment.

6. Proximity of the U12 snRNA with both the 5' splice site and the branch point during early stages of spliceosome assembly.

7. Functional spliceosomal A complexes can be assembled in vitro in the absence of a penta-snRNP.

8. The abundance of the spliceosomal snRNPs is not limiting the splicing of U12-type introns.

9. Enhancer-dependent 5'-splice site control of fruitless pre-mRNA splicing.

10. Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection.