Literature DB >> 11804425

Ethical dimensions of the number of embryos to be transferred in in vitro fertilization.

F A Chervenak1, L B McCullough, Z Rosenwaks.   

Abstract

PURPOSE: We propose an ethically justified policy for the number of embryos to transfer in an in vitro fertilization (IVF), by considering fourfactors: medical outcomes, patient's preferences, costs, and market forces of providers.
METHODS: We develop an ethical framework that incorporates three ethical principles: beneficence, respect for autonomy, and justice; and three professional virtues: integrity, compassion, and self-sacrifice.
RESULTS: This ethical framework calls for an informed consent process for IVF that provides: information about medical outcomes; information about the risks of multiple gestation; the opportunity to weigh the goal of pregnancy and live birth against the medical and moral risks of multiple gestation; evidence-based recommendations; protection of the woman from potentially coercive influences; and discussion of living with infertility and going to better centers.
CONCLUSION: The number of embryos to be transferred in IVF should mainly be a function of the pregnant women's informed decision. Limiting the number of transferred embryos to two in all cases is not ethically justified at this time.

Entities:  

Mesh:

Year:  2001        PMID: 11804425      PMCID: PMC3455696          DOI: 10.1023/a:1013104820518

Source DB:  PubMed          Journal:  J Assist Reprod Genet        ISSN: 1058-0468            Impact factor:   3.412


  11 in total

1.  Two's company, three's a crowd for embryo transfer.

Authors:  N M Fisk; G Trew
Journal:  Lancet       Date:  1999-11-06       Impact factor: 79.321

2.  Estimating the risk of cerebral palsy after assisted conceptions.

Authors:  I Blickstein; A Weissman
Journal:  N Engl J Med       Date:  1999-10-21       Impact factor: 91.245

3.  (Almost) everything you ever wanted to know about informed consent. [Review of: Faden, RR and Beauchamp, TL. A history and theory of informed concsent. New York and Oxford: Oxford University Press, 1986].

Authors:  A M Capron
Journal:  Med Humanit Rev       Date:  1987-01

Review 4.  Can the epidemic of iatrogenic multiples be conquered?

Authors:  B R Hecht; M W Magoon
Journal:  Clin Obstet Gynecol       Date:  1998-03       Impact factor: 2.190

5.  IVF in the US: multiple gestation, economic competition, and the necessity of excess.

Authors:  K Faber
Journal:  Hum Reprod       Date:  1997-08       Impact factor: 6.918

6.  Live-birth rates and multiple-birth risk using in vitro fertilization.

Authors:  L A Schieve; H B Peterson; S F Meikle; G Jeng; I Danel; N M Burnett; L S Wilcox
Journal:  JAMA       Date:  1999-11-17       Impact factor: 56.272

7.  Deliveries and children born after in-vitro fertilisation in Sweden 1982-95: a retrospective cohort study.

Authors:  T Bergh; A Ericson; T Hillensjö; K G Nygren; U B Wennerholm
Journal:  Lancet       Date:  1999-11-06       Impact factor: 79.321

8.  A triplet pregnancy after in vitro fertilization is a procedure-related complication that should be prevented by replacement of two embryos only.

Authors:  J Roest; A M van Heusden; A Verhoeff; H V Mous; G H Zeilmaker
Journal:  Fertil Steril       Date:  1997-02       Impact factor: 7.329

9.  The transfer of two embryos instead of three to reduce the risk of multiple pregnancy: a retrospective analysis.

Authors:  P L Matson; J Browne; R Deakin; B Bellinge
Journal:  J Assist Reprod Genet       Date:  1999-01       Impact factor: 3.412

10.  How many embryos should be transferred in in vitro fertilization? A prospective randomized study.

Authors:  D Vauthier-Brouzes; G Lefebvre; S Lesourd; J Gonzales; Y Darbois
Journal:  Fertil Steril       Date:  1994-08       Impact factor: 7.329

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