Literature DB >> 11799200

Differential activation of influenza A virus endonuclease activity is dependent on multiple sequence differences between the virion RNA and cRNA promoters.

Michael B Leahy1, Giuseppe Zecchin, George G Brownlee.   

Abstract

Influenza virus endonuclease activity was studied in vitro with model virion RNA (vRNA) and cRNA molecules. We show that endonuclease activity can be partially rescued by transplanting vRNA-like promoter features into the model cRNA promoter. This study defines three distinctive features within the vRNA promoter--absent in the cRNA promoter--that are required for endonuclease cleavage.

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Year:  2002        PMID： 11799200      PMCID： PMC135883          DOI： 10.1128/jvi.76.4.2019-2023.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  16 in total

1.  Distinct regions of influenza virus PB1 polymerase subunit recognize vRNA and cRNA templates.

Authors:  S González; J Ortín
Journal:  EMBO J       Date:  1999-07-01       Impact factor: 11.598

2.  Mutagenic analysis of the 5' arm of the influenza A virus virion RNA promoter defines the sequence requirements for endonuclease activity.

Authors:  M B Leahy; D C Pritlove; L L Poon; G G Brownlee
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

3.  Hairpin loop structure in the 3' arm of the influenza A virus virion RNA promoter is required for endonuclease activity.

Authors:  M B Leahy; H C Dobbyn; G G Brownlee
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

4.  Structure of the ribonucleoprotein of influenza virus.

Authors:  R W Compans; J Content; P H Duesberg
Journal:  J Virol       Date:  1972-10       Impact factor: 5.103

5.  The genes of influenza virus.

Authors:  P Palese
Journal:  Cell       Date:  1977-01       Impact factor: 41.582

6.  Cap-recognizing protein of influenza virus.

Authors:  D Blaas; E Patzelt; E Kuechler
Journal:  Virology       Date:  1982-01-15       Impact factor: 3.616

7.  Characterization of influenza virus RNA complete transcripts.

Authors:  A J Hay; J J Skehel; J McCauley
Journal:  Virology       Date:  1982-01-30       Impact factor: 3.616

8.  Identification of the cap binding protein of influenza virus.

Authors:  D Blaas; E Patzelt; E Kuechler
Journal:  Nucleic Acids Res       Date:  1982-08-11       Impact factor: 16.971

9.  Synthesis and cellular location of the ten influenza polypeptides individually expressed by recombinant vaccinia viruses.

Authors:  G L Smith; J Z Levin; P Palese; B Moss
Journal:  Virology       Date:  1987-10       Impact factor: 3.616

10.  Recombinant influenza virus polymerase: requirement of both 5' and 3' viral ends for endonuclease activity.

Authors:  M Hagen; T D Chung; J A Butcher; M Krystal
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103
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  11 in total

1.  NF-kappaB signaling differentially regulates influenza virus RNA synthesis.

Authors:  Naveen Kumar; Zhong-Tao Xin; Yuhong Liang; Hinh Ly; Yuying Liang
Journal:  J Virol       Date:  2008-08-13       Impact factor: 5.103

2.  Role of the conserved nucleotide mismatch within 3'- and 5'-terminal regions of Bunyamwera virus in signaling transcription.

Authors:  John N Barr; Gail W Wertz
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

3.  The Bunyamwera virus mRNA transcription signal resides within both the 3' and the 5' terminal regions and allows ambisense transcription from a model RNA segment.

Authors:  John N Barr; John W Rodgers; Gail W Wertz
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

4.  Structural characterization of the viral and cRNA panhandle motifs from the infectious salmon anemia virus.

Authors:  Robert G Brinson; Andrea L Szakal; John P Marino
Journal:  J Virol       Date:  2011-10-12       Impact factor: 5.103

5.  Crucial role of CA cleavage sites in the cap-snatching mechanism for initiating viral mRNA synthesis.

Authors:  Ping Rao; Weiming Yuan; Robert M Krug
Journal:  EMBO J       Date:  2003-03-03       Impact factor: 11.598

6.  Solution structure of the influenza A virus cRNA promoter: implications for differential recognition of viral promoter structures by RNA-dependent RNA polymerase.

Authors:  Chin-Ju Park; Sung-Hun Bae; Mi-Kyung Lee; Gabriele Varani; Byong-Seok Choi
Journal:  Nucleic Acids Res       Date:  2003-06-01       Impact factor: 16.971

7.  Bunyamwera bunyavirus RNA synthesis requires cooperation of 3'- and 5'-terminal sequences.

Authors:  John N Barr; Gail W Wertz
Journal:  J Virol       Date:  2004-02       Impact factor: 5.103

8.  Mutational analysis of the Uukuniemi virus (Bunyaviridae family) promoter reveals two elements of functional importance.

Authors:  Ramon Flick; Fredrik Elgh; Ralf F Pettersson
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

9.  A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs.

Authors:  Ervin Fodor; Mandy Crow; Louise J Mingay; Tao Deng; Jane Sharps; Pierre Fechter; George G Brownlee
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

10.  Different de novo initiation strategies are used by influenza virus RNA polymerase on its cRNA and viral RNA promoters during viral RNA replication.

Authors:  Tao Deng; Frank T Vreede; George G Brownlee
Journal:  J Virol       Date:  2006-03       Impact factor: 5.103
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