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Literature DB >> 11796380

Integron-located oxa-32 gene cassette encoding an extended-spectrum variant of OXA-2 beta-lactamase from Pseudomonas aeruginosa.

Laurent Poirel¹, Patrick Gerome, Christophe De Champs, Jean Stephanazzi, Thierry Naas, Patrice Nordmann.

Abstract

Pseudomonas aeruginosa clinical isolate CY-1, which was resistant to ceftazidime, harbored a conjugative ca. 250-kb plasmid that contained a class 1 integron with two gene cassettes encoding OXA-32, an OXA-2- type beta-lactamase, and the aminoglycoside acetyltransferase AAC(6')Ib(9). OXA-32 differed from OXA-2 by an Leu169Ile amino acid substitution (class D numbering). Site-directed mutagenesis established that Ile169 is responsible for resistance to ceftazidime but not to cefotaxime.

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Year: 2002 PMID： 11796380 PMCID： PMC127075 DOI： 10.1128/AAC.46.2.566-569.2002

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

19 in total

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2. Extended-spectrum beta-lactamases in Pseudomonas aeruginosa.

Authors: P Nordmann; M Guibert
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Journal: Antimicrob Agents Chemother Date: 2001-02 Impact factor: 5.191

Review 5. Class 1 integrons, gene cassettes, mobility, and epidemiology.

Authors: A C Fluit; F J Schmitz
Journal: Eur J Clin Microbiol Infect Dis Date: 1999-11 Impact factor: 3.267

6. Carbapenems as inhibitors of OXA-13, a novel, integron-encoded beta-lactamase in Pseudomonas aeruginosa.

Authors: P Mugnier; I Podglajen; F W Goldstein; E Collatz
Journal: Microbiology (Reading) Date: 1998-04 Impact factor: 2.777

7. New plasmid-mediated oxacillin-hydrolyzing beta-lactamase in Pseudomonas aeruginosa.

Authors: A M Philippon; G C Paul; G A Jacoby
Journal: J Antimicrob Chemother Date: 1986-04 Impact factor: 5.790

8. Sequence of the OXA2 beta-lactamase: comparison with other penicillin-reactive enzymes.

Authors: J W Dale; D Godwin; D Mossakowska; P Stephenson; S Wall
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Review 9. OXA-type beta-lactamases.

Authors: T Naas; P Nordmann
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10. OXA-24, a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain.

Authors: G Bou; A Oliver; J Martínez-Beltrán
Journal: Antimicrob Agents Chemother Date: 2000-06 Impact factor: 5.191

16 in total

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Review 2. Aminoglycoside resistance in Pseudomonas aeruginosa.

Authors: Keith Poole
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3. Association of plasmid-mediated quinolone resistance with extended-spectrum beta-lactamase VEB-1.

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4. Detection of the novel extended-spectrum beta-lactamase OXA-161 from a plasmid-located integron in Pseudomonas aeruginosa clinical isolates from Spain.

Authors: C Juan; X Mulet; L Zamorano; S Albertí; J L Pérez; A Oliver
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5. Strain-tailored double-disk synergy test detects extended-spectrum oxacillinases in Pseudomonas aeruginosa.

Authors: Didier Hocquet; Barbara Dehecq; Xavier Bertrand; Patrick Plésiat
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6. CTX-M-2 and a new CTX-M-39 enzyme are the major extended-spectrum beta-lactamases in multiple Escherichia coli clones isolated in Tel Aviv, Israel.

Authors: Inna Chmelnitsky; Yehuda Carmeli; Azita Leavitt; Mitchell J Schwaber; Shiri Navon-Venezia
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7. OXA-163, an OXA-48-related class D β-lactamase with extended activity toward expanded-spectrum cephalosporins.

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Journal: Antimicrob Agents Chemother Date: 2011-03-21 Impact factor: 5.191

8. Genetic structure associated with blaOXA-18, encoding a clavulanic acid-inhibited extended-spectrum oxacillinase.

Authors: Thierry Naas; Fatemeh Namdari; Pierre Bogaerts; Te-Din Huang; Youri Glupczynski; Patrice Nordmann
Journal: Antimicrob Agents Chemother Date: 2008-07-28 Impact factor: 5.191

9. Class D β-lactamases: are they all carbapenemases?

Authors: Nuno T Antunes; Toni L Lamoureaux; Marta Toth; Nichole K Stewart; Hilary Frase; Sergei B Vakulenko
Journal: Antimicrob Agents Chemother Date: 2014-01-27 Impact factor: 5.191

10. Prospective survey of beta-lactamases produced by ceftazidime- resistant Pseudomonas aeruginosa isolated in a French hospital in 2000.

Authors: Christophe De Champs; Laurent Poirel; Richard Bonnet; Danielle Sirot; Catherine Chanal; Jacques Sirot; Patrice Nordmann
Journal: Antimicrob Agents Chemother Date: 2002-09 Impact factor: 5.191