Literature DB >> 11796255

Alzheimer's and Parkinson's disease--overlapping or synergistic pathologies?

Pascal Kurosinski, Mathias Guggisberg, Jürgen Götz.   

Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative disorders in humans. They are characterized by insoluble protein deposits; beta-amyloid plaques and tau-containing neurofibrillary lesions in AD, and alpha-synuclein-containing Lewy bodies in PD. As a significant percentage of patients have clinical and pathological features of both diseases, the patho-cascades of the two diseases might overlap. For the first time, new animal models that express multiple transgenes provide the tools to dissect the pathogenic pathways and to differentiate between additive and synergistic effects.

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Year:  2002        PMID： 11796255     DOI： 10.1016/s1471-4914(01)02246-8

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  19 in total

1.  Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease.

Authors:  D W Tsuang; R K Wilson; O L Lopez; E K Luedecking-Zimmer; J B Leverenz; S T DeKosky; M I Kamboh; R L Hamilton
Journal:  Neurology       Date:  2005-02-08       Impact factor: 9.910

Review 2.  Neuroproteomics as a promising tool in Parkinson's disease research.

Authors:  Ilse S Pienaar; William M U Daniels; Jürgen Götz
Journal:  J Neural Transm (Vienna)       Date:  2008-06-04       Impact factor: 3.575

3.  Primary support cultures of hippocampal and substantia nigra neurons.

Authors:  Thomas Fath; Yazi D Ke; Peter Gunning; Jürgen Götz; Lars M Ittner
Journal:  Nat Protoc       Date:  2009       Impact factor: 13.491

Review 4.  Redox proteomics in some age-related neurodegenerative disorders or models thereof.

Authors:  D Allan Butterfield; Hafiz Mohmmad Abdul; Shelley Newman; Tanea Reed
Journal:  NeuroRx       Date:  2006-07

Review 5.  Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues.

Authors:  Lars M Ittner; Matthias Klugmann; Yazi D Ke
Journal:  Br J Pharmacol       Date:  2019-04-23       Impact factor: 8.739

6.  Neurodegeneration across stages of cognitive decline in Parkinson disease.

Authors:  Daniel Weintraub; Jimit Doshi; Deepthi Koka; Christos Davatzikos; Andrew D Siderowf; John E Duda; David A Wolk; Paul J Moberg; Sharon X Xie; Christopher M Clark
Journal:  Arch Neurol       Date:  2011-12

Review 7.  Role of the chanzyme TRPM7 in the nervous system in health and disease.

Authors:  Nashat Abumaria; Wei Li; Andrew N Clarkson
Journal:  Cell Mol Life Sci       Date:  2019-05-09       Impact factor: 9.261

8.  Determination of the activation energy for unimolecular dissociation of a non-covalent gas-phase peptide: substrate complex by infrared multiphoton dissociation fourier transform ion cyclotron resonance mass spectrometry.

Authors:  Mathias Schäfer; Carsten Schmuck; Martin Heil; Helen J Cooper; Christopher L Hendrickson; Michael J Chalmers; Alan G Marshall
Journal:  J Am Soc Mass Spectrom       Date:  2003-11       Impact factor: 3.109

9.  Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro.

Authors:  Irina L Derkatch; Susan M Uptain; Tiago F Outeiro; Rajaraman Krishnan; Susan L Lindquist; Susan W Liebman
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-23       Impact factor: 11.205

10.  A possible relationship between telomere length and markers of neurodegeneration in rat brain after welding fume inhalation exposure.

Authors:  Mohammad Shoeb; Gul M Mustafa; Vamsi K Kodali; Kelly Smith; Katherine A Roach; Gregory Boyce; Terence Meighan; Jenny R Roberts; Aaron Erdely; James M Antonini
Journal:  Environ Res       Date:  2019-11-05       Impact factor: 6.498
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