Literature DB >> 11796242

Calmodulin is a limiting factor in the cell.

Anthony Persechini1, Paul M Stemmer.   

Abstract

The total intracellular concentration of calmodulin (CaM) in the cell appears to be significantly below the total concentration of its targets, making it a limiting factor in their regulation. In this review we discuss the ways in which this is likely to impact signaling. A key conclusion is that competition for a limiting pool of CaM enables cross-talk between CaM-dependent signaling pathways.

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Year:  2002        PMID： 11796242     DOI： 10.1016/s1050-1738(01)00144-x

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  58 in total

1.  Calmodulin potentiates G beta gamma activation of phospholipase C-beta3.

Authors:  Jennifer S McCullar; Dean A Malencik; Walter K Vogel; Kristi M Crofoot; Sonia R Anderson; Theresa M Filtz
Journal:  Biochem Pharmacol       Date:  2006-10-13       Impact factor: 5.858

2.  Tertiary structural rearrangements upon oxidation of Methionine145 in calmodulin promotes targeted proteasomal degradation.

Authors:  Colette A Sacksteder; Jennifer E Whittier; Yijia Xiong; Jinhui Li; Nadezhda A Galeva; Michael E Jacoby; Samuel O Purvine; Todd D Williams; Martin C Rechsteiner; Diana J Bigelow; Thomas C Squier
Journal:  Biophys J       Date:  2006-06-02       Impact factor: 4.033

3.  Modulation of skeletal and cardiac voltage-gated sodium channels by calmodulin.

Authors:  Katharine A Young; John H Caldwell
Journal:  J Physiol       Date:  2005-03-03       Impact factor: 5.182

4.  Arrestin binding to calmodulin: a direct interaction between two ubiquitous signaling proteins.

Authors:  Nan Wu; Susan M Hanson; Derek J Francis; Sergey A Vishnivetskiy; Marc Thibonnier; Candice S Klug; Menachem Shoham; Vsevolod V Gurevich
Journal:  J Mol Biol       Date:  2006-10-03       Impact factor: 5.469

5.  Recognition of β-calcineurin by the domains of calmodulin: thermodynamic and structural evidence for distinct roles.

Authors:  Susan E O'Donnell; Liping Yu; C Andrew Fowler; Madeline A Shea
Journal:  Proteins       Date:  2010-12-06

6.  Genetic polymorphism and protein conformational plasticity in the calmodulin superfamily: two ways to promote multifunctionality.

Authors:  Mitsuhiko Ikura; James B Ames
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-23       Impact factor: 11.205

7.  Variations at the semiconserved glycine in the IQ domain consensus sequence have a major impact on Ca2+-dependent switching in calmodulin-IQ domain complexes.

Authors:  D J Black; Anthony Persechini
Journal:  Biochemistry       Date:  2010-01-12       Impact factor: 3.162

8.  Real-time evaluation of myosin light chain kinase activation in smooth muscle tissues from a transgenic calmodulin-biosensor mouse.

Authors:  Eiji Isotani; Gang Zhi; Kim S Lau; Jian Huang; Yusuke Mizuno; Anthony Persechini; Ramaz Geguchadze; Kristine E Kamm; James T Stull
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-07       Impact factor: 11.205

9.  Spatial diffusivity and availability of intracellular calmodulin.

Authors:  Hugo Sanabria; Michelle A Digman; Enrico Gratton; M Neal Waxham
Journal:  Biophys J       Date:  2008-09-26       Impact factor: 4.033

10.  Translational switch for long-term maintenance of synaptic plasticity.

Authors:  Naveed Aslam; Yoshi Kubota; David Wells; Harel Z Shouval
Journal:  Mol Syst Biol       Date:  2009-06-16       Impact factor: 11.429
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