OBJECTIVE: to clarify and confirm the renoprotective effects of ACEIs in Japanese type 1 diabetics. RESEARCH DESIGN AND METHODS: a double-blind randomized study using two ACEIs, imidapril (a prodrug of imdaprilat without an SH-residue) and captopril as well as placebo was performed. Seventy-nine eligible cases were randomized to receive captopril 37.5 mg (n=26), imidapril 5 mg (n=26) or their placebos (n=27) daily in a double-blind manner. RESULTS:urinary albumin excretion (UAE), determined every half year, was significantly decreased by the ACEIs (placebo vs. ACEIs F=11.316, P=0.001, placebo vs. captopril F=4.260, P=0.043, placebo vs. imidapril F=14.341, P<0.001) during the study period (the mean; 1.48 years). Although the HbA(1C) levels and systolic blood pressure (BP) between the three groups were not different, glycemic and BP control significantly affected UAE. Systolic BP in the placebo group tended to be higher by 7-10 mmHg throughout the study. CONCLUSIONS: these results suggest that the ACE inhibitors, imidapril and captopril, prevent the increase in UAE in micro and macroalbuminuric patients with type 1 diabetes mellitus and that the target BP might be less than 130/80 mmHg.
RCT Entities:
OBJECTIVE: to clarify and confirm the renoprotective effects of ACEIs in Japanese type 1 diabetics. RESEARCH DESIGN AND METHODS: a double-blind randomized study using two ACEIs, imidapril (a prodrug of imdaprilat without an SH-residue) and captopril as well as placebo was performed. Seventy-nine eligible cases were randomized to receive captopril 37.5 mg (n=26), imidapril 5 mg (n=26) or their placebos (n=27) daily in a double-blind manner. RESULTS: urinary albumin excretion (UAE), determined every half year, was significantly decreased by the ACEIs (placebo vs. ACEIs F=11.316, P=0.001, placebo vs. captopril F=4.260, P=0.043, placebo vs. imidapril F=14.341, P<0.001) during the study period (the mean; 1.48 years). Although the HbA(1C) levels and systolic blood pressure (BP) between the three groups were not different, glycemic and BP control significantly affected UAE. Systolic BP in the placebo group tended to be higher by 7-10 mmHg throughout the study. CONCLUSIONS: these results suggest that the ACE inhibitors, imidapril and captopril, prevent the increase in UAE in micro and macroalbuminuric patients with type 1 diabetes mellitus and that the target BP might be less than 130/80 mmHg.
Authors: Ionel Alexandru Checheriţă; Gina Manda; Mihai Eugen Hinescu; Ileana Peride; Andrei Niculae; Ştefana Bîlha; Angelica Grămăticu; Luminiţa Voroneanu; Adrian Covic Journal: Int Urol Nephrol Date: 2016-01-12 Impact factor: 2.370
Authors: Jingchuan Guo; Ashley I Naimi; Maria M Brooks; Matthew F Muldoon; Trevor J Orchard; Tina Costacou Journal: Ann Epidemiol Date: 2019-12-06 Impact factor: 3.797
Authors: Kiyoshi Kurokawa; Juliana C N Chan; Mark E Cooper; William F Keane; Shahnaz Shahinfar; Zhongxin Zhang Journal: Clin Exp Nephrol Date: 2006-09 Impact factor: 2.801