Literature DB >> 11794526

Cytotoxic alkaloids from Houttuynia cordata.

S K Kim1, S Y Ryu, J No, S U Choi, Y S Kim.   

Abstract

Six bioactive alkaloids, aristolactam B(1), piperolactam A(2), aristolactam A(3), norcepharadione B(4), cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionation of a methanolic extract of the aerial part of Houttuynia cordata. Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.

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Year:  2001        PMID： 11794526     DOI： 10.1007/bf02975156

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  14 in total

1.  Norcepharadione B attenuates H2O2-induced neuronal injury by upregulating cellular antioxidants and inhibiting volume-sensitive Cl- channel.

Authors:  Xin Jia; Yan Liu; Xing Li; Cong Huo; Dongtao Li; Rong Xu; Liming Hou; Xiaoming Wang
Journal:  Exp Biol Med (Maywood)       Date:  2019-10-04

Review 2.  A current update on the phytopharmacological aspects of Houttuynia cordata Thunb.

Authors:  Manish Kumar; Satyendra K Prasad; S Hemalatha
Journal:  Pharmacogn Rev       Date:  2014-01

3.  Alteration in brain-derived neurotrophic factor (BDNF) after treatment of mice with herbal mixture containing Euphoria longana, Houttuynia cordata and Dioscorea japonica.

Authors:  Songhee Jeon; Chia-Hung Lee; Quan Feng Liu; Geun Woo Kim; Byung-Soo Koo; Sok Cheon Pak
Journal:  Daru       Date:  2014-11-28       Impact factor: 3.117

4.  Pharmaceutical Impact of Houttuynia Cordata and Metformin Combination on High-Fat-Diet-Induced Metabolic Disorders: Link to Intestinal Microbiota and Metabolic Endotoxemia.

Authors:  Jing-Hua Wang; Shambhunath Bose; Na Rae Shin; Young-Won Chin; Young Hee Choi; Hojun Kim
Journal:  Front Endocrinol (Lausanne)       Date:  2018-10-24       Impact factor: 5.555

5.  Total synthesis of aristolactam alkaloids via synergistic C-H bond activation and dehydro-Diels-Alder reactions.

Authors:  Mallu Chenna Reddy; Masilamani Jeganmohan
Journal:  Chem Sci       Date:  2017-03-23       Impact factor: 9.825

6.  Anticomplementary principles of a Chinese multiherb remedy for the treatment and prevention of SARS.

Authors:  Ting Zhang; Daofeng Chen
Journal:  J Ethnopharmacol       Date:  2008-02-17       Impact factor: 4.360

7.  Anthelmintic activities of aporphine from Nelumbo nucifera Gaertn. cv. Rosa-plena against Hymenolepis nana.

Authors:  Rong-Jyh Lin; Mei-Hsuan Wu; Yi-Hsuan Ma; Li-Yu Chung; Chung-Yi Chen; Chuan-Min Yen
Journal:  Int J Mol Sci       Date:  2014-02-27       Impact factor: 5.923

8.  Antihyperglycemic Activity of Houttuynia cordata Thunb. in Streptozotocin-Induced Diabetic Rats.

Authors:  Manish Kumar; Satyendra K Prasad; Sairam Krishnamurthy; Siva Hemalatha
Journal:  Adv Pharmacol Sci       Date:  2014-02-24

9.  Optimization of potassium for proper growth and physiological response of Houttuynia cordata Thunb.

Authors:  Y Wen Xu; Yu Ting Zou; Amjad M Husaini; Jian Wei Zeng; Lin Liang Guan; Qian Liu; Wei Wu
Journal:  Environ Exp Bot       Date:  2010-12-29       Impact factor: 5.545

10.  Immunomodulatory and anti-SARS activities of Houttuynia cordata.

Authors:  Kit-Man Lau; Kin-Ming Lee; Chi-Man Koon; Crystal Sao-Fong Cheung; Ching-Po Lau; Hei-Ming Ho; Mavis Yuk-Ha Lee; Shannon Wing-Ngor Au; Christopher Hon-Ki Cheng; Clara Bik-San Lau; Stephen Kwok-Wing Tsui; David Chi-Cheong Wan; Mary Miu-Yee Waye; Kam-Bo Wong; Chun-Kwok Wong; Christopher Wai-Kei Lam; Ping-Chung Leung; Kwok-Pui Fung
Journal:  J Ethnopharmacol       Date:  2008-03-30       Impact factor: 4.360
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