| Literature DB >> 11789592 |
L M Xiu1, A B Miura, K Yamamoto, T Kobayashi, Q H Song, H Kitamura, J C Cyong.
Abstract
In this experiment, we investigated the effects of crude Ephedrae herba, alkaloid extract of Ephedrae herba and 1-ephedrine, a major alkaloid component, on diabetic mice induced by streptozotocin (STZ). The alkaloid extract and 1-ephedrine showed suppression on the hyperglycemia. The suppression by Ephedrae herba of hyperglycemia may therefore be due to 1-ephedrine. Furthermore, we found that Ephedrae herba, alkaloid and 1-ephedrine promoted the regeneration of pancreas islets following atrophy induced by STZ. It is therefore suggested that Ephedrae herba may regenerate atrophied pancreatic islets, restore the secretion of insulin, and thus correct hyperglycemia.Entities:
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Year: 2001 PMID： 11789592 DOI： 10.1142/S0192415X01000514
Source DB: PubMed Journal: Am J Chin Med ISSN： 0192-415X Impact factor: 4.667