| Literature DB >> 11786922 |
Marco Colasanti1, Luigi Gradoni, Marco Mattu, Tiziana Persichini, Luca Salvati, Giorgio Venturini, Paolo Ascenzi.
Abstract
Nitric oxide (NO) has emerged as an important cytotoxic and cytostatic effector for a number of pathogens, including viruses, bacteria, fungi, and parasites. When the microbicidal effect of NO occurs, the NO-mediated S-nitrosylation of cysteine containing proteins (e.g., cysteine proteases) appears to be a common and widespread mechanism. This overview concerns parasitic cysteine proteases as NO targets, providing molecular bases for the parasiticidal effect of NO.Entities:
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Year: 2002 PMID： 11786922
Source DB: PubMed Journal: Int J Mol Med ISSN： 1107-3756 Impact factor: 4.101