Literature DB >> 11780784

Simocyclinones: diversity of metabolites is dependent on fermentation conditions.

J Schimana1, M Walker, A Zeeck, P Fiedler.   

Abstract

Simocyclinones, a novel group of angucyclinone antibiotics, are produced by Streptomyces antibioticus Tü 6040. The compounds show antibacterial and antitumor properties. In submerged cultivation, the production of simocyclinones is strongly dependent on the carbon and nitrogen sources used in a chemically defined medium. Productivity of distinct components and diversity of simocyclinone compounds are influenced by the medium composition. Four series of simocyclinone compounds were detected by high-performance liquid chromatography (HPLC) diode array detector (DAD) and HPLC electrospray ionization (ESI) mass spectrometry (MS) analysis, isolated and the structures determined by nuclear magnetic resonance (NMR) techniques. Under optimized conditions, simocyclinone D8 was produced in an amount of 300 mg l(-1) and simocyclinone C4 in a concentration up to 50 mg l(-1).

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Year:  2001        PMID： 11780784     DOI： 10.1038/sj.jim.7000024

Source DB:  PubMed          Journal:  J Ind Microbiol Biotechnol        ISSN： 1367-5435            Impact factor:   3.346


  9 in total

1.  Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.

Authors:  A Trefzer; S Pelzer; J Schimana; S Stockert; C Bihlmaier; H-P Fiedler; K Welzel; A Vente; A Bechthold
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

Review 2.  Astonishing diversity of natural surfactants: 4. Fatty acid amide glycosides, their analogs and derivatives.

Authors:  Valery M Dembitsky
Journal:  Lipids       Date:  2005-07       Impact factor: 1.880

Review 3.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

4.  Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action.

Authors:  Ruth H Flatman; Alison J Howells; Lutz Heide; Hans-Peter Fiedler; Anthony Maxwell
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

5.  SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors.

Authors:  Liliya Horbal; Yuriy Rebets; Mariya Rabyk; Roman Makitrynskyy; Andriy Luzhetskyy; Victor Fedorenko; Andreas Bechthold
Journal:  AMB Express       Date:  2012-01-03       Impact factor: 3.298

6.  SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone.

Authors:  Martin Schäfer; Tung B K Le; Stephen J Hearnshaw; Anthony Maxwell; Gregory L Challis; Barrie Wilkinson; Mark J Buttner
Journal:  J Mol Biol       Date:  2015-04-08       Impact factor: 5.469

7.  Genome-guided Investigation of Antibiotic Substances produced by Allosalinactinospora lopnorensis CA15-2(T) from Lop Nor region, China.

Authors:  Chen Huang; Ross Ka-Kit Leung; Min Guo; Li Tuo; Lin Guo; Wing Wai Yew; Inchio Lou; Simon Ming Yuen Lee; Chenghang Sun
Journal:  Sci Rep       Date:  2016-02-11       Impact factor: 4.379

Review 8.  Structural insights into simocyclinone as an antibiotic, effector ligand and substrate.

Authors:  Mark J Buttner; Martin Schäfer; David M Lawson; Anthony Maxwell
Journal:  FEMS Microbiol Rev       Date:  2018-01-01       Impact factor: 16.408

9.  Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate.

Authors:  Martin Schäfer; Clare E M Stevenson; Barrie Wilkinson; David M Lawson; Mark J Buttner
Journal:  Cell Chem Biol       Date:  2016-09-08       Impact factor: 8.116
  9 in total

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