Literature DB >> 1177963

Cycloheximide resistance in Chinese hamster cells. II. Induction of Chm resistance in Chinese hamster cells by N-nitrosomethylurea.

H Pöche, N B Varshaver, M Theille, E Geissler.   

Abstract

Mutant Chinese hamster ovarian (CHO) cells with a resistance to 7-10(-7) and 8-10(-7) M cycloheximide (CHM) were induced at mutation rates of 1.9-5.2-10(-3) and 1.6-1.8-10(-3) respectively after treatment with N-nitrosomethylurea (NMU) at 100 mug/ml. The induced mutation rates differed by two orders of magnitude from the spontaneous rate of mutation to CHM resistance.

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Year:  1975        PMID： 1177963     DOI： 10.1016/0027-5107(75)90256-0

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  3 in total

1.  Resistance against cycloheximide in cell lines from Chinese hamster and human cells is conferred by the large subunit of cytoplasmic ribosomes.

Authors:  H Pöche; S Zakrzewski; K H Nierhaus
Journal:  Mol Gen Genet       Date:  1979-09

2.  Cycloheximide-resistance in Chinese hamster ovary cells and human fibroblast cells. Cytogenetic and biochemical characterization.

Authors:  H Pöche; K H Nierhaus; S Zakrzewski
Journal:  Hum Genet       Date:  1979-09       Impact factor: 4.132

3.  Emetine resistance in chinese hamster ovary cells is associated with an altered ribosomal protein S14 mRNA.

Authors:  J J Madjar; K Nielsen-Smith; M Frahm; D J Roufa
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205
  3 in total

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