Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Recombination at double-strand breaks and DNA ends: conserved mechanisms from phage to humans.

Literature DB >> 11779493

Recombination at double-strand breaks and DNA ends: conserved mechanisms from phage to humans.

Abstract

The recombination mechanisms that deal with double-strand breaks in organisms as diverse as phage, bacteria, yeast, and humans are remarkably conserved. We discuss conservation in the biochemical pathways required to recombine DNA ends and in the structure of the DNA products. In addition, we highlight that two fundamentally distinct broken DNA substrates exist and describe how they are repaired differently by recombination. Finally, we discuss the need to coordinate recombinational repair with cell division through DNA damage response pathways.

Entities: Species

Mesh：

Substances：
DNA

Year: 2001 PMID： 11779493 DOI： 10.1016/s1097-2765(01)00419-1

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

Keyword Cloud
Cited

124 in total

1. RecFOR function is required for DNA repair and recombination in a RecA loading-deficient recB mutant of Escherichia coli.

Authors: Ivana Ivancić-Baće; Petra Peharec; Suncana Moslavac; Nikolina Skrobot; Erika Salaj-Smic; Krunoslav Brcić-Kostić
Journal: Genetics Date: 2003-02 Impact factor: 4.562

2. Coordination of DNA ends during double-strand-break repair in bacteriophage T4.

Authors: Bradley A Stohr; Kenneth N Kreuzer
Journal: Genetics Date: 2002-11 Impact factor: 4.562

3. DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.

Authors: Martijn de Jager; Claire Wyman; Dik C van Gent; Roland Kanaar
Journal: Nucleic Acids Res Date: 2002-10-15 Impact factor: 16.971

4. Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast.

Authors: Yufuko Akamatsu; Dorota Dziadkowiec; Mitsunori Ikeguchi; Hideo Shinagawa; Hiroshi Iwasaki
Journal: Proc Natl Acad Sci U S A Date: 2003-12-08 Impact factor: 11.205

10. Single-Homology-Arm Linear DNA Recombination by the Nonhomologous End Joining Pathway as a Novel and Simple Gene Inactivation Method: a Proof-of-Concept Study in Dietzia sp. Strain DQ12-45-1b.

Authors: Shelian Lu; Yong Nie; Meng Wang; Hong-Xiu Xu; Dong-Ling Ma; Jie-Liang Liang; Xiao-Lei Wu
Journal: Appl Environ Microbiol Date: 2018-09-17 Impact factor: 4.792

Recombination at double-strand breaks and DNA ends: conserved mechanisms from phage to humans.

1. RecFOR function is required for DNA repair and recombination in a RecA loading-deficient recB mutant of Escherichia coli.

2. Coordination of DNA ends during double-strand-break repair in bacteriophage T4.

3. DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.

4. Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast.

5. Replication fork collapse at replication terminator sequences.

6. The coiled-coil of the human Rad50 DNA repair protein contains specific segments of increased flexibility.

7. Rad52 and Ku bind to different DNA structures produced early in double-strand break repair.

8. Pathways of DNA double-strand break repair during the mammalian cell cycle.

9. Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.

10. Single-Homology-Arm Linear DNA Recombination by the Nonhomologous End Joining Pathway as a Novel and Simple Gene Inactivation Method: a Proof-of-Concept Study in Dietzia sp. Strain DQ12-45-1b.