Literature DB >> 11779456

Why is p53 acetylated?

C Prives1, J L Manley.   

Abstract

Recent studies suggest that acetylation of the p53 tumor suppressor protein is not important for its DNA binding activity, as was previously thought. We discuss here a number of theories as to how this modification may serve to regulate the protein's functions.

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Year:  2001        PMID： 11779456     DOI： 10.1016/s0092-8674(01)00619-5

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  64 in total

1.  Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase alpha-primase.

Authors:  Christian Melle; Heinz-Peter Nasheuer
Journal:  Nucleic Acids Res       Date:  2002-04-01       Impact factor: 16.971

2.  A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes.

Authors:  Jagat C Borah; Shiraz Mujtaba; Ioannis Karakikes; Lei Zeng; Michaela Muller; Jigneshkumar Patel; Natasha Moshkina; Keita Morohashi; Weijia Zhang; Guillermo Gerona-Navarro; Roger J Hajjar; Ming-Ming Zhou
Journal:  Chem Biol       Date:  2011-04-22

3.  Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells.

Authors:  Eun-Taex Oh; Moon-Taek Park; Bo-Hwa Choi; Seonggu Ro; Eun-Kyung Choi; Seong-Yun Jeong; Heon Joo Park
Journal:  Invest New Drugs       Date:  2010-10-27       Impact factor: 3.850

4.  Impairment of p53 acetylation, stability and function by an oncogenic transcription factor.

Authors:  Alessandra Insinga; Silvia Monestiroli; Simona Ronzoni; Roberta Carbone; Mark Pearson; Giancarlo Pruneri; Giuseppe Viale; Ettore Appella; PierGiuseppe Pelicci; Saverio Minucci
Journal:  EMBO J       Date:  2004-02-19       Impact factor: 11.598

5.  The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53.

Authors:  David Dornan; Harumi Shimizu; Lindsay Burch; Amanda J Smith; Ted R Hupp
Journal:  Mol Cell Biol       Date:  2003-12       Impact factor: 4.272

Review 6.  Transcriptional activators and activation mechanisms.

Authors:  Jun Ma
Journal:  Protein Cell       Date:  2011-12-17       Impact factor: 14.870

7.  Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

Authors:  Carol Imbriano; Aymone Gurtner; Fabienne Cocchiarella; Silvia Di Agostino; Valentina Basile; Monica Gostissa; Matthias Dobbelstein; Giannino Del Sal; Giulia Piaggio; Roberto Mantovani
Journal:  Mol Cell Biol       Date:  2005-05       Impact factor: 4.272

8.  Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway.

Authors:  Hoon Ryu; Junghee Lee; Beatrix A Olofsson; Aziza Mwidau; Alpaslan Dedeoglu; Maria Escudero; Erik Flemington; Jane Azizkhan-Clifford; Robert J Ferrante; Rajiv R Ratan; Alpaslan Deodoglu
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-14       Impact factor: 11.205

9.  Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone.

Authors:  Noé Galván; Sophia Lim; Stephan Zmugg; Martyn T Smith; Luoping Zhang
Journal:  Mutat Res       Date:  2007-08-07       Impact factor: 2.433

Review 10.  The expanding universe of p53 targets.

Authors:  Daniel Menendez; Alberto Inga; Michael A Resnick
Journal:  Nat Rev Cancer       Date:  2009-10       Impact factor: 60.716
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