Literature DB >> 11777882

The potential role of prehospital administration of activated charcoal.

S Thakore1, N Murphy.   

Abstract

OBJECTIVES: Activated charcoal is now the mainstay of non-specific treatment for self poisoning in accident and emergency (A&E) departments and should be administered within one hour of ingestion of an overdose. This study aimed to investigate if compliance with treatment guidelines may be improved by the prehospital administration of activated charcoal.
METHOD: Ambulance report forms and case notes were reviewed in all patients presenting to A&E by ambulance after self poisoning. Information was gathered using a standardised abstraction form. The times collected were: time of ingestion, time of call to ambulance control, time picked up, time of arrival in A&E and time seen by doctor.
RESULTS: 201 patient records were reviewed. Twenty six were excluded because of incomplete data on report forms or case notes. The median time between ingestion and pick up by an ambulance crew was 77 minutes. This compares with a median of 140 minutes for the time to assessment by medical staff. Seventy three patients were picked up by an ambulance within one hour of overdose, only 11 (15%) of these were seen by medical staff within an hour of ingestion. Forty nine of these 73 patients would have been suitable candidates to receive activated charcoal.
CONCLUSIONS: The prehospital administration of charcoal provides an opportunity to comply with international guidelines on reducing the absorption of a potentially fatal overdose. The administration of charcoal results in few side effects provided the patient can adequately protect their airway and ambulance staff could be trained in its use. Further studies would be necessary to investigate if this would effect clinical outcome.

Entities:  

Mesh:

Substances:

Year:  2002        PMID: 11777882      PMCID: PMC1725753          DOI: 10.1136/emj.19.1.63

Source DB:  PubMed          Journal:  Emerg Med J        ISSN: 1472-0205            Impact factor:   2.740


  13 in total

Review 1.  Gastrointestinal decontamination after poisoning. Where is the science?

Authors:  A S Manoguerra
Journal:  Crit Care Clin       Date:  1997-10       Impact factor: 3.598

Review 2.  Position statement: gastric lavage. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists.

Authors:  J A Vale
Journal:  J Toxicol Clin Toxicol       Date:  1997

Review 3.  Position statement: single-dose activated charcoal. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists.

Authors:  P A Chyka; D Seger
Journal:  J Toxicol Clin Toxicol       Date:  1997

4.  Fatal pulmonary aspiration of oral activated charcoal.

Authors:  D G Menzies; A Busuttil; L F Prescott
Journal:  BMJ       Date:  1988-08-13

Review 5.  Gastric decontamination--a view for the millennium.

Authors:  D N Bateman
Journal:  J Accid Emerg Med       Date:  1999-03

6.  Efficacy of ipecac-induced emesis, orogastric lavage, and activated charcoal for acute drug overdose.

Authors:  M Tenenbein; S Cohen; D S Sitar
Journal:  Ann Emerg Med       Date:  1987-08       Impact factor: 5.721

7.  A comparison of the efficacy of gastric lavage, ipecacuanha and activated charcoal in the emergency management of paracetamol overdose.

Authors:  T J Underhill; M K Greene; A F Dove
Journal:  Arch Emerg Med       Date:  1990-09

8.  Gastric emptying in acute overdose: a prospective randomised controlled trial.

Authors:  S M Pond; D J Lewis-Driver; G M Williams; A C Green; N W Stevenson
Journal:  Med J Aust       Date:  1995-10-02       Impact factor: 7.738

9.  Comparison of three methods of gut decontamination in tricyclic antidepressant overdose.

Authors:  G M Bosse; J A Barefoot; M P Pfeifer; G C Rodgers
Journal:  J Emerg Med       Date:  1995 Mar-Apr       Impact factor: 1.484

10.  Gastric emptying procedures in the self-poisoned patient: are we forcing gastric content beyond the pylorus?

Authors:  J P Saetta; S March; M E Gaunt; D N Quinton
Journal:  J R Soc Med       Date:  1991-05       Impact factor: 18.000

View more
  4 in total

Review 1.  Acute poisoning: understanding 90% of cases in a nutshell.

Authors:  S L Greene; P I Dargan; A L Jones
Journal:  Postgrad Med J       Date:  2005-04       Impact factor: 2.401

2.  Prehospital activated charcoal: the way forward.

Authors:  S L Greene; M Kerins; N O'Connor
Journal:  Emerg Med J       Date:  2005-10       Impact factor: 2.740

3.  Feasibility of prehospital treatment with activated charcoal: Who could we treat, who should we treat?

Authors:  G K Isbister; A H Dawson; I M Whyte
Journal:  Emerg Med J       Date:  2003-07       Impact factor: 2.740

4.  The feasibility of administration of activated charcoal with respect to current practice guidelines in emergency department patients.

Authors:  Frank LoVecchio; J Shriki; K Innes; J Bermudez
Journal:  J Med Toxicol       Date:  2007-09
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.