Literature DB >> 11773968

Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats.

Michael R Garrett1, John P Rapp.   

Abstract

Linkage analysis previously demonstrated a blood pressure quantitative trait locus (QTL) on rat Chromosome 2 (Chr 2) in crosses utilizing Dahl salt-sensitive (S) rats. The present work dissects this QTL by using congenic strains in which segments of Chr 2 from Wistar Kyoto rats (WKY) are placed on the S genetic background. Two distinct QTLs were found where one QTL was anticipated. These each accounted for a blood pressure of 15-20 mm Hg in rats fed 2% NaCl diet for 24 days. One QTL was in the <9-cM interval between D2Rat35 and D2Wox18 (Fgg), and the other was in the <7-cM interval between D2Wox18 (Fgg) and D2Mgh10. A third tentative QTL was suggested, but not clearly established, in the <3-cM interval between D2Mgh10 and D2Rat259.

Entities:  

Mesh：

Year:  2002        PMID： 11773968     DOI： 10.1007/s00335-001-2114-y

Source DB:  PubMed          Journal:  Mamm Genome        ISSN： 0938-8990            Impact factor:   2.957


  14 in total

Review 1.  Functional genomics in rodent models of hypertension.

Authors:  Martin W McBride; Fadi J Charchar; Delyth Graham; William H Miller; Pamela Strahorn; Fiona J Carr; Anna F Dominiczak
Journal:  J Physiol       Date:  2004-01-01       Impact factor: 5.182

2.  Use of contiguous congenic strains in analyzing compound QTLs.

Authors:  John P Rapp; Bina Joe
Journal:  Physiol Genomics       Date:  2011-11-22       Impact factor: 3.107

Review 3.  Finding the molecular basis of complex genetic variation in humans and mice.

Authors:  Richard Mott
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-03-29       Impact factor: 6.237

4.  Dr Lewis Kitchener Dahl, the Dahl rats, and the "inconvenient truth" about the genetics of hypertension.

Authors:  Bina Joe
Journal:  Hypertension       Date:  2015-02-02       Impact factor: 10.190

5.  Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs.

Authors:  Zhiyun Wei; Kuixing Zhang; Gen Wen; Karthika Balasubramanian; Pei-an B Shih; Fangwen Rao; Ryan S Friese; Jose P Miramontes-Gonzalez; Geert W Schmid-Schoenbein; Hyung-Suk Kim; Sushil K Mahata; Daniel T O'Connor
Journal:  J Hypertens       Date:  2013-01       Impact factor: 4.844

6.  Investigating the effect of genetic background on proteinuria and renal injury using two hypertensive strains.

Authors:  Matthew Packard; Yasser Saad; William T Gunning; Shalini Gupta; Joseph Shapiro; Michael R Garrett
Journal:  Am J Physiol Renal Physiol       Date:  2009-01-28

7.  Genetically hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension.

Authors:  Marijo Bilusić; Carol Moreno; Nadia E Barreto; Michael R Tschannen; Eugenie L Harris; William K Porteous; Caryn M Thompson; Murray R Grigor; Alan Weder; Eric Boerwinkle; Steven C Hunt; J David Curb; Howard J Jacob; Anne E Kwitek
Journal:  Croat Med J       Date:  2008-10       Impact factor: 1.351

8.  Genetic architecture of quantitative traits in mice, flies, and humans.

Authors:  Jonathan Flint; Trudy F C Mackay
Journal:  Genome Res       Date:  2009-05       Impact factor: 9.043

Review 9.  Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.

Authors:  Sandosh Padmanabhan; Bina Joe
Journal:  Physiol Rev       Date:  2017-10-01       Impact factor: 37.312

10.  Chromosome 2 Fragment Substitutions in Dahl Salt-Sensitive Rats and RNA Sequencing Identified Enpep and Hs2st1 as Vascular Inflammatory Modulators.

Authors:  Olga Berillo; Sofiane Ouerd; Noureddine Idris-Khodja; Asia Rehman; Chantal Richer; Daniel Sinnett; Anne E Kwitek; Pierre Paradis; Ernesto L Schiffrin
Journal:  Hypertension       Date:  2020-11-09       Impact factor: 10.190
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.