| Literature DB >> 1176595 |
K Okuda, K Ito, K Miyake, M Morita, M Ogonuki.
Abstract
A large-scale procedure for purification and concentration of Japanese encephalitis virus vaccine by a continuous-flow isopycnic banding technique in a sucrose density gradient solution, using a K-III zonal centrifuge rotor, is presented. The quality of zonal-purified vaccine was compared with commercial and Japanese National Institutes of Health reference vaccines for antigenicity, immunodiffusion, and allergic encephalitogenicity tests to show its high purity.Entities:
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Year: 1975 PMID: 1176595 PMCID: PMC274950 DOI: 10.1128/jcm.1.1.96-101.1975
Source DB: PubMed Journal: J Clin Microbiol ISSN: 0095-1137 Impact factor: 5.948