OBJECTIVE: To identify chromosomal regions containing genes involved in the susceptibility to human systemic lupus erythematosus (SLE)-related traits. METHODS: In the context of a genome scan, we analyzed 101 SLE-affected sibpairs with respect to dermatologic, renal, immunologic, hematologic, neurologic, cardiopulmonary, and arthritic characteristics. Phenotypes were redefined in terms of principal components, which are synthetic variables composed of linear combinations of the original traits. Using 9 principal components obtained from these 7 traits plus age at SLE onset and race, we analyzed genome scan data with the multivariate version of the new Haseman-Elston regression model. RESULTS: The largest linkage for an individual trait was on chromosome 2 at 228 cM (immunologic; P = 0.00048). The most significant linkage to an individual principal component was on chromosome 4 at 208 cM (P = 0.00007). The largest multivariate linkage was on chromosome 7 at 69 cM (P = 0.0001). Of the individual organ systems, dermatologic involvement had the largest effect (P = 0.0083) at this peak at 7p13 on chromosome 7. Further analyses revealed that malar rash, a subtype of dermatologic involvement, was linked significantly (P = 0.00458) to this location. CONCLUSION: These results provide evidence of the presence and locations of genes that are involved in the genetic susceptibility to SLE-related traits in humans.
OBJECTIVE: To identify chromosomal regions containing genes involved in the susceptibility to humansystemic lupus erythematosus (SLE)-related traits. METHODS: In the context of a genome scan, we analyzed 101 SLE-affected sibpairs with respect to dermatologic, renal, immunologic, hematologic, neurologic, cardiopulmonary, and arthritic characteristics. Phenotypes were redefined in terms of principal components, which are synthetic variables composed of linear combinations of the original traits. Using 9 principal components obtained from these 7 traits plus age at SLE onset and race, we analyzed genome scan data with the multivariate version of the new Haseman-Elston regression model. RESULTS: The largest linkage for an individual trait was on chromosome 2 at 228 cM (immunologic; P = 0.00048). The most significant linkage to an individual principal component was on chromosome 4 at 208 cM (P = 0.00007). The largest multivariate linkage was on chromosome 7 at 69 cM (P = 0.0001). Of the individual organ systems, dermatologic involvement had the largest effect (P = 0.0083) at this peak at 7p13 on chromosome 7. Further analyses revealed that malar rash, a subtype of dermatologic involvement, was linked significantly (P = 0.00458) to this location. CONCLUSION: These results provide evidence of the presence and locations of genes that are involved in the genetic susceptibility to SLE-related traits in humans.
Authors: Cynthia M Bulik; B Devlin; Silviu-Alin Bacanu; Laura Thornton; Kelly L Klump; Manfred M Fichter; Katherine A Halmi; Allan S Kaplan; Michael Strober; D Blake Woodside; Andrew W Bergen; J Kelly Ganjei; Scott Crow; James Mitchell; Alessandro Rotondo; Mauro Mauri; Giovanni Cassano; Pamela Keel; Wade H Berrettini; Walter H Kaye Journal: Am J Hum Genet Date: 2002-12-10 Impact factor: 11.025
Authors: Chao Xing; Courtney Gray-McGuire; Jennifer A Kelly; Phillip Garriott; Hulya Bukulmez; John B Harley; Jane M Olson Journal: Hum Genet Date: 2005-09-28 Impact factor: 4.132
Authors: Astrid Rasmussen; Sydney Sevier; Jennifer A Kelly; Stuart B Glenn; Teresa Aberle; Carisa M Cooney; Anya Grether; Ellen James; Jared Ning; Joanne Tesiram; Jean Morrisey; Tiny Powe; Mark Drexel; Wes Daniel; Bahram Namjou; Joshua O Ojwang; Kim L Nguyen; Joshua W Cavett; Jeannie L Te; Judith A James; R Hal Scofield; Kathy Moser; Gary S Gilkeson; Diane L Kamen; Craig W Carson; Ana I Quintero-del-Rio; Maria del Carmen Ballesteros; Marilynn G Punaro; David R Karp; Daniel J Wallace; Michael Weisman; Joan T Merrill; Roberto Rivera; Michelle A Petri; Daniel A Albert; Luis R Espinoza; Tammy O Utset; Timothy S Shaver; Eugene Arthur; Juan-Manuel Anaya; Gail R Bruner; John B Harley Journal: Rheumatology (Oxford) Date: 2010-09-23 Impact factor: 7.580
Authors: Cheryl L Thompson; Benjamin A Rybicki; Michael C Iannuzzi; Robert C Elston; Sudha K Iyengar; Courtney Gray-McGuire Journal: Am J Hum Genet Date: 2006-08-10 Impact factor: 11.025
Authors: Henrik Christian Bidstrup Leffers; Anne Troldborg; Anne Voss; Salome Kristensen; Jesper Lindhardsen; Prabhat Kumar; Asta Linauskas; Lars Juul; Niels Steen Krogh; Bent Deleuran; Lene Dreyer; Søren Jacobsen Journal: Lupus Sci Med Date: 2021-04