Literature DB >> 11758932

Chemical synthesis and biological activity of the gelatinase biosynthesis-activating pheromone of Enterococcus faecalis and its analogs.

J Nakayama1, Y Cao, T Horii, S Sakuda, H Nagasawa.   

Abstract

An 11-residue peptide lactone, termed the gelatinase biosynthesis-activating pheromone (GBAP), triggers the production of the pathogenicity-related extracellular proteases, gelatinase and serine protease, in Enterococcus faecalis. In this study, we synthesized GBAP and its analogs and examined their gelatinase biosynthesis-inducing activity. This study on the structure-activity relationship shows that a lactone ring was indispensable for the activity.

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Year:  2001        PMID： 11758932     DOI： 10.1271/bbb.65.2322

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  18 in total

Review 1.  Peptide signaling in the staphylococci.

Authors:  Matthew Thoendel; Jeffrey S Kavanaugh; Caralyn E Flack; Alexander R Horswill
Journal:  Chem Rev       Date:  2010-12-21       Impact factor: 60.622

2.  Revised model for Enterococcus faecalis fsr quorum-sensing system: the small open reading frame fsrD encodes the gelatinase biosynthesis-activating pheromone propeptide corresponding to staphylococcal agrd.

Authors:  Jiro Nakayama; Shengmin Chen; Nozomi Oyama; Kenzo Nishiguchi; Essam A Azab; Emi Tanaka; Reiko Kariyama; Kenji Sonomoto
Journal:  J Bacteriol       Date:  2006-09-15       Impact factor: 3.490

3.  Enterococcus faecalis virulence regulator FsrA binding to target promoters.

Authors:  María Florencia Del Papa; Marta Perego
Journal:  J Bacteriol       Date:  2011-01-21       Impact factor: 3.490

4.  N-Methylation of Amino Acids in Gelatinase Biosynthesis-Activating Pheromone Identifies Key Site for Stability Enhancement with Retention of the Enterococcus faecalis fsr Quorum Sensing Circuit Response.

Authors:  Dominic N McBrayer; Brooke K Gantman; Yftah Tal-Gan
Journal:  ACS Infect Dis       Date:  2019-04-19       Impact factor: 5.084

5.  Description of a 23.9-kilobase chromosomal deletion containing a region encoding fsr genes which mainly determines the gelatinase-negative phenotype of clinical isolates of Enterococcus faecalis in urine.

Authors:  Jiro Nakayama; Reiko Kariyama; Hiromi Kumon
Journal:  Appl Environ Microbiol       Date:  2002-06       Impact factor: 4.792

6.  Comparison of OG1RF and an isogenic fsrB deletion mutant by transcriptional analysis: the Fsr system of Enterococcus faecalis is more than the activator of gelatinase and serine protease.

Authors:  Agathe Bourgogne; Susan G Hilsenbeck; Gary M Dunny; Barbara E Murray
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

7.  Multiple roles for Enterococcus faecalis glycosyltransferases in biofilm-associated antibiotic resistance, cell envelope integrity, and conjugative transfer.

Authors:  Jennifer L Dale; Julian Cagnazzo; Chi Q Phan; Aaron M T Barnes; Gary M Dunny
Journal:  Antimicrob Agents Chemother       Date:  2015-04-27       Impact factor: 5.191

8.  Siamycin attenuates fsr quorum sensing mediated by a gelatinase biosynthesis-activating pheromone in Enterococcus faecalis.

Authors:  Jiro Nakayama; Emi Tanaka; Reiko Kariyama; Koji Nagata; Kenzo Nishiguchi; Ritsuko Mitsuhata; Yumi Uemura; Masaru Tanokura; Hiromi Kumon; Kenji Sonomoto
Journal:  J Bacteriol       Date:  2006-10-27       Impact factor: 3.490

9.  Structure-activity relationship of gelatinase biosynthesis-activating pheromone of Enterococcus faecalis.

Authors:  Kenzo Nishiguchi; Koji Nagata; Masaru Tanokura; Kenji Sonomoto; Jiro Nakayama
Journal:  J Bacteriol       Date:  2008-11-07       Impact factor: 3.490

10.  Rational Design of Potent Activators and Inhibitors of the Enterococcus faecalis Fsr Quorum Sensing Circuit.

Authors:  Dominic N McBrayer; Crissey D Cameron; Brooke K Gantman; Yftah Tal-Gan
Journal:  ACS Chem Biol       Date:  2018-09-07       Impact factor: 5.100
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