Literature DB >> 12039782

Description of a 23.9-kilobase chromosomal deletion containing a region encoding fsr genes which mainly determines the gelatinase-negative phenotype of clinical isolates of Enterococcus faecalis in urine.

Jiro Nakayama1, Reiko Kariyama, Hiromi Kumon.   

Abstract

Expression of virulence-related extracellular proteases, gelatinase, and serine protease of Enterococcus faecalis is regulated by a quorum-sensing system encoded by the fsr gene cluster. In this study, a 23.9-kb chromosomal deletion containing the fsr gene cluster region was found to be present in the majority (79%) of gelatinase-negative clinical isolates of E. faecalis from urine.

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Year:  2002        PMID： 12039782      PMCID： PMC123941          DOI： 10.1128/AEM.68.6.3152-3155.2002

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  15 in total

1.  Chemical synthesis and biological activity of the gelatinase biosynthesis-activating pheromone of Enterococcus faecalis and its analogs.

Authors:  J Nakayama; Y Cao; T Horii; S Sakuda; H Nagasawa
Journal:  Biosci Biotechnol Biochem       Date:  2001-10       Impact factor: 2.043

2.  Characterization of fsr, a regulator controlling expression of gelatinase and serine protease in Enterococcus faecalis OG1RF.

Authors:  X Qin; K V Singh; G M Weinstock; B E Murray
Journal:  J Bacteriol       Date:  2001-06       Impact factor: 3.490

3.  Genetic organization of the chromosome region surrounding mecA in clinical staphylococcal strains: role of IS431-mediated mecI deletion in expression of resistance in mecA-carrying, low-level methicillin-resistant Staphylococcus haemolyticus.

Authors:  Y Katayama; T Ito; K Hiramatsu
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

4.  The prevalence of enterococci in the human mouth and their pathogenicity in animal models.

Authors:  O G Gold; H V Jordan; J van Houte
Journal:  Arch Oral Biol       Date:  1975-07       Impact factor: 2.633

5.  Gelatinase biosynthesis-activating pheromone: a peptide lactone that mediates a quorum sensing in Enterococcus faecalis.

Authors:  J Nakayama; Y Cao; T Horii; S Sakuda; A D Akkermans; W M de Vos; H Nagasawa
Journal:  Mol Microbiol       Date:  2001-07       Impact factor: 3.501

6.  A simple model host for identifying Gram-positive virulence factors.

Authors:  D A Garsin; C D Sifri; E Mylonakis; X Qin; K V Singh; B E Murray; S B Calderwood; F M Ausubel
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-04       Impact factor: 11.205

7.  Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence.

Authors:  X Qin; K V Singh; G M Weinstock; B E Murray
Journal:  Infect Immun       Date:  2000-05       Impact factor: 3.441

8.  Molecular screening of Enterococcus virulence determinants and potential for genetic exchange between food and medical isolates.

Authors:  T J Eaton; M J Gasson
Journal:  Appl Environ Microbiol       Date:  2001-04       Impact factor: 4.792

9.  Nucleotide sequence of the gelatinase gene (gelE) from Enterococcus faecalis subsp. liquefaciens.

Authors:  Y A Su; M C Sulavik; P He; K K Makinen; P L Makinen; S Fiedler; R Wirth; D B Clewell
Journal:  Infect Immun       Date:  1991-01       Impact factor: 3.441

10.  Persistence of colonization of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus GG, after oral consumption.

Authors:  M Alander; R Satokari; R Korpela; M Saxelin; T Vilpponen-Salmela; T Mattila-Sandholm; A von Wright
Journal:  Appl Environ Microbiol       Date:  1999-01       Impact factor: 4.792
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  34 in total

1.  Lack of correlation of gelatinase production and biofilm formation in a large collection of Enterococcus faecalis isolates.

Authors:  Jamal A Mohamed; Barbara E Murray
Journal:  J Clin Microbiol       Date:  2005-10       Impact factor: 5.948

2.  Revised model for Enterococcus faecalis fsr quorum-sensing system: the small open reading frame fsrD encodes the gelatinase biosynthesis-activating pheromone propeptide corresponding to staphylococcal agrd.

Authors:  Jiro Nakayama; Shengmin Chen; Nozomi Oyama; Kenzo Nishiguchi; Essam A Azab; Emi Tanaka; Reiko Kariyama; Kenji Sonomoto
Journal:  J Bacteriol       Date:  2006-09-15       Impact factor: 3.490

3.  Diversity of the fsr-gelE region of the Enterococcus faecalis genome but conservation in strains with partial deletions of the fsr operon.

Authors:  Jessica R Galloway-Peña; Agathe Bourgogne; Xiang Qin; Barbara E Murray
Journal:  Appl Environ Microbiol       Date:  2010-11-19       Impact factor: 4.792

Review 4.  Pathogenicity of Enterococci.

Authors:  Elizabeth Fiore; Daria Van Tyne; Michael S Gilmore
Journal:  Microbiol Spectr       Date:  2019-07

5.  Fsr-independent production of protease(s) may explain the lack of attenuation of an Enterococcus faecalis fsr mutant versus a gelE-sprE mutant in induction of endocarditis.

Authors:  Kavindra V Singh; Sreedhar R Nallapareddy; Esteban C Nannini; Barbara E Murray
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

6.  Comparison of OG1RF and an isogenic fsrB deletion mutant by transcriptional analysis: the Fsr system of Enterococcus faecalis is more than the activator of gelatinase and serine protease.

Authors:  Agathe Bourgogne; Susan G Hilsenbeck; Gary M Dunny; Barbara E Murray
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

7.  Multiple roles for Enterococcus faecalis glycosyltransferases in biofilm-associated antibiotic resistance, cell envelope integrity, and conjugative transfer.

Authors:  Jennifer L Dale; Julian Cagnazzo; Chi Q Phan; Aaron M T Barnes; Gary M Dunny
Journal:  Antimicrob Agents Chemother       Date:  2015-04-27       Impact factor: 5.191

8.  Molecular characterization of a widespread, pathogenic, and antibiotic resistance-receptive Enterococcus faecalis lineage and dissemination of its putative pathogenicity island.

Authors:  Sreedhar R Nallapareddy; Huang Wenxiang; George M Weinstock; Barbara E Murray
Journal:  J Bacteriol       Date:  2005-08       Impact factor: 3.490

9.  Molecular epidemiology of the fsr locus and of gelatinase production among different subsets of Enterococcus faecalis isolates.

Authors:  Jill C Roberts; Kavindra V Singh; Pablo C Okhuysen; Barbara E Murray
Journal:  J Clin Microbiol       Date:  2004-05       Impact factor: 5.948

10.  A fratricidal mechanism is responsible for eDNA release and contributes to biofilm development of Enterococcus faecalis.

Authors:  Vinai Chittezham Thomas; Yasuaki Hiromasa; Nathan Harms; Lance Thurlow; John Tomich; Lynn E Hancock
Journal:  Mol Microbiol       Date:  2009-04-21       Impact factor: 3.501
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