Literature DB >> 11758928

Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis.

K Yamamoto1, T Kitayama, S Minagawa, T Watanabe, S Sawada, T Okamoto, R Utsumi.   

Abstract

We demonstrated in vitro that YycG-YycF of Bacillus subtilis constitutes a two-component system and shows a specificity of the sensor protein for the cognate phosphorylation partner. Based on inhibition of such an autophosphorylation of YycG, we searched imidazole and zerumbone derivatives to identify the antibacterial agents such as NH125, NH126, NH127, and NH0891.

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Year:  2001        PMID： 11758928     DOI： 10.1271/bbb.65.2306

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  22 in total

1.  YycH regulates the activity of the essential YycFG two-component system in Bacillus subtilis.

Authors:  Hendrik Szurmant; Kristine Nelson; Eun-Ja Kim; Marta Perego; James A Hoch
Journal:  J Bacteriol       Date:  2005-08       Impact factor: 3.490

2.  Development of an antivirulence drug against Streptococcus mutans: repression of biofilm formation, acid tolerance, and competence by a histidine kinase inhibitor, walkmycin C.

Authors:  Yoko Eguchi; Norihiro Kubo; Hiroko Matsunaga; Masayuki Igarashi; Ryutaro Utsumi
Journal:  Antimicrob Agents Chemother       Date:  2011-01-31       Impact factor: 5.191

3.  NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption.

Authors:  Wooseong Kim; Nico Fricke; Annie L Conery; Beth Burgwyn Fuchs; Rajmohan Rajamuthiah; Elamparithi Jayamani; Petia M Vlahovska; Frederick M Ausubel; Eleftherios Mylonakis
Journal:  Future Med Chem       Date:  2016-02-24       Impact factor: 3.808

4.  Kinetic characterization of the WalRKSpn (VicRK) two-component system of Streptococcus pneumoniae: dependence of WalKSpn (VicK) phosphatase activity on its PAS domain.

Authors:  Alina D Gutu; Kyle J Wayne; Lok-To Sham; Malcolm E Winkler
Journal:  J Bacteriol       Date:  2010-02-26       Impact factor: 3.490

5.  Influence of subinhibitory concentrations of NH125 on biofilm formation & virulence factors of Staphylococcus aureus.

Authors:  Qingzhong Liu; Zhaojun Zheng; Wooseong Kim; Beth Burgwyn Fuchs; Eleftherios Mylonakis
Journal:  Future Med Chem       Date:  2018-05-30       Impact factor: 3.808

Review 6.  Essential Two-Component Systems Regulating Cell Envelope Functions: Opportunities for Novel Antibiotic Therapies.

Authors:  Silvia T Cardona; Matthew Choy; Andrew M Hogan
Journal:  J Membr Biol       Date:  2017-11-02       Impact factor: 1.843

Review 7.  Synthesis of histidine kinase inhibitors and their biological properties.

Authors:  Miyanou Rosales-Hurtado; Patrick Meffre; Hendrik Szurmant; Zohra Benfodda
Journal:  Med Res Rev       Date:  2019-12-05       Impact factor: 12.944

Review 8.  Strategies against methicillin-resistant Staphylococcus aureus persisters.

Authors:  Wooseong Kim; Gabriel L Hendricks; Katerina Tori; Beth B Fuchs; Eleftherios Mylonakis
Journal:  Future Med Chem       Date:  2018-03-23       Impact factor: 3.808

9.  Thiazolidione derivatives targeting the histidine kinase YycG are effective against both planktonic and biofilm-associated Staphylococcus epidermidis.

Authors:  Ren-zheng Huang; Li-kang Zheng; Hua-yong Liu; Bin Pan; Jian Hu; Tao Zhu; Wei Wang; Dan-bin Jiang; Yang Wu; You-cong Wu; Shi-qing Han; Di Qu
Journal:  Acta Pharmacol Sin       Date:  2012-01-09       Impact factor: 6.150

10.  Isolation and characterization of signermycin B, an antibiotic that targets the dimerization domain of histidine kinase WalK.

Authors:  Takafumi Watanabe; Masayuki Igarashi; Toshihide Okajima; Eiji Ishii; Hirokazu Kino; Masaki Hatano; Ryuichi Sawa; Maya Umekita; Tomoyuki Kimura; Sho Okamoto; Yoko Eguchi; Yuzuru Akamatsu; Ryutaro Utsumi
Journal:  Antimicrob Agents Chemother       Date:  2012-04-23       Impact factor: 5.191
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