BACKGROUND: Optical coherence tomography (OCT) is a high-resolution imaging technique that produces cross-sectional images in vivo. This is a report of the first use of OCT to acquire images of the biliary tree during ERCP. METHODS: A 2.6-mm diameter OCT catheter delivered through the accessory channel of a duodenoscope was used to acquire images of the intrahepatic and extrahepatic bile ducts in 5 patients. Histology-correlated OCT images of 5 cadaveric livers, each imaged at 3 sites, were used to guide interpretation of the in vivo images. RESULTS: Biliary ductal epithelium and subepithelial structures, including peribiliary glands, vasculature, and hepatic parenchyma, were visualized in vivo. The papillary architecture of cholangiocarcinoma was identified by OCT. There were no OCT-related complications. CONCLUSIONS: High-resolution OCT imaging of the biliary tree is feasible and may provide useful diagnostic information during ERCP.
BACKGROUND: Optical coherence tomography (OCT) is a high-resolution imaging technique that produces cross-sectional images in vivo. This is a report of the first use of OCT to acquire images of the biliary tree during ERCP. METHODS: A 2.6-mm diameter OCT catheter delivered through the accessory channel of a duodenoscope was used to acquire images of the intrahepatic and extrahepatic bile ducts in 5 patients. Histology-correlated OCT images of 5 cadaveric livers, each imaged at 3 sites, were used to guide interpretation of the in vivo images. RESULTS: Biliary ductal epithelium and subepithelial structures, including peribiliary glands, vasculature, and hepatic parenchyma, were visualized in vivo. The papillary architecture of cholangiocarcinoma was identified by OCT. There were no OCT-related complications. CONCLUSIONS: High-resolution OCT imaging of the biliary tree is feasible and may provide useful diagnostic information during ERCP.
Authors: John A Evans; Brett E Bouma; Jason Bressner; Milen Shishkov; Gregory Y Lauwers; Mari Mino-Kenudson; Norman S Nishioka; Guillermo J Tearney Journal: Gastrointest Endosc Date: 2006-09-20 Impact factor: 9.427
Authors: John A Evans; John M Poneros; Brett E Bouma; Jason Bressner; Elkan F Halpern; Milen Shishkov; Gregory Y Lauwers; Mari Mino-Kenudson; Norman S Nishioka; Guillermo J Tearney Journal: Clin Gastroenterol Hepatol Date: 2006-01 Impact factor: 11.382
Authors: Benjamin J Vakoc; Milen Shishko; Seok H Yun; Wang-Yuhl Oh; Melissa J Suter; Adrien E Desjardins; John A Evans; Norman S Nishioka; Guillermo J Tearney; Brett E Bouma Journal: Gastrointest Endosc Date: 2007-03-26 Impact factor: 9.427
Authors: Mohammad S Mahmud; Gray R May; Mohammad M Kamal; Ahmed S Khwaja; Carry Sun; Alex Vitkin; Victor Xd Yang Journal: World J Gastrointest Endosc Date: 2013-11-16