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Literature DB >> 1175561

Acute liver injury by vinyl chloride: involvement of endoplasmic reticulum in phenobarbital-pretreated rats.

Abstract

A single 6-hr exposure to vinyl chloride monomer (5%) produces extensive vacuolization of centrolobular liver parenchyma and focal midzonal necrosis in the hepatic lobuole in phenobarbital-pretreated rats. Ultrastructurally, vacuolization consists of dilation of cysternae of rough endoplasmic reticulum and in the same cells smooth endoplasmic reticulum coalesces into discreet aggregates resembling denatured membranes. The findings support the hypothesis that vinyl chloride is hepatotoxic because it is converted into a toxic metabolite by components of the mixed function oxidase system of liver endoplasmic reticulum.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1975 PMID： 1175561 PMCID： PMC1475197 DOI： 10.1289/ehp.7511227

Source DB: PubMed Journal: Environ Health Perspect ISSN： 0091-6765 Impact factor: 9.031

11 in total

1. Effects of single and repeated exposures of humans and rats to vinyl chloride.

Authors: D LESTER; L A GREENBERG; W R ADAMS
Journal: Am Ind Hyg Assoc J Date: 1963 May-Jun

2. Chemical carcinogenesis: a long-neglected field blossoms.

Authors: T H Maugh
Journal: Science Date: 1974-03-08 Impact factor: 47.728

3. Angiosarcoma of the liver following vinyl chloride exposure.

Authors: J B Block
Journal: JAMA Date: 1974-07-01 Impact factor: 56.272

4. Effect of 18 hr fast and glutathione depletion on 1,1-dichloroethylene-induced hepatotoxicity and lethality in rats.

Authors: R J Jaeger; R B Conolly; S D Murphy
Journal: Exp Mol Pathol Date: 1974-04 Impact factor: 3.362

5. Liver injury following halothane anesthesia in phenobarbital-pretreated rats.

Authors: E S Reynolds; M T Moslen
Journal: Biochem Pharmacol Date: 1974-01-15 Impact factor: 5.858

Review 6. The role of theliver in drug metabolism.

Authors: H Remmer
Journal: Am J Med Date: 1970-11 Impact factor: 4.965

7. Carbon tetrachloride-induced protection against carbon tetrachloride toxicity. The role of the liver microsomal drug-metabolizing system.

Authors: E A Glende
Journal: Biochem Pharmacol Date: 1972-06-15 Impact factor: 5.858

Acute liver injury by vinyl chloride: involvement of endoplasmic reticulum in phenobarbital-pretreated rats.

1. Effects of single and repeated exposures of humans and rats to vinyl chloride.

2. Chemical carcinogenesis: a long-neglected field blossoms.

3. Angiosarcoma of the liver following vinyl chloride exposure.

4. Effect of 18 hr fast and glutathione depletion on 1,1-dichloroethylene-induced hepatotoxicity and lethality in rats.

5. Liver injury following halothane anesthesia in phenobarbital-pretreated rats.

Review 6. The role of theliver in drug metabolism.

7. Carbon tetrachloride-induced protection against carbon tetrachloride toxicity. The role of the liver microsomal drug-metabolizing system.

8. Microsomal lipid peroxidation: morphological characterization.

9. Liver parenchymal cell injury. 8. Lesions of membranous cellular components following iodoform.

10. Biochemical toxicology of unsaturated halogenated monomers.

1. Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.

2. Effects of vinyl chloride exposures to rats pretreated with phenobarbital.

3. Chemistry and toxicity of flame retardants for plastics.