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Literature DB >> 241261

Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.

E S Reynolds, M T Moslen, S Szabo, R J Jaeger, S D Murphy.

Abstract

Vinyl chloride, an occupational carcinogen, produces acute liver injury in rats pretreated with phenobarbital or Aroclor 1254. Injury appears related to morphologic changes in the endoplasmic reticulum. The degree of injury, as indicated by elevation of serum enzymes derived from the liver, correlates with the magnitude of induction of cytochrome P-450 and its reduction by NADPH. Hepatic injury following 1,1-dichloroethylene exposure differs strikingly from that caused by vinyl chloride and appears to involve plasma membranes, mitochondria, and chromatin and spares endoplasmic reticulum. Induction of cytochrome P-450 appears to protect against 1,1-dichloroethylene but not vinyl chloride.

Entities: Chemical Disease Gene Species

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Year: 1975 PMID： 241261 PMCID： PMC2032287

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

24 in total

1. THE METABOLISM OF 36C1-LABELLED TRICHLOROETHYLENE AND TETRACHLOROETHYLENE IN THE RAT.

Authors: J W DANIEL
Journal: Biochem Pharmacol Date: 1963-08 Impact factor: 5.858

2. Metabolism of trichloroethylene in liver microsomes. 3. Induction of the enzymic activity and its effect on excretion of metabolites.

Authors: K C Leibman; W J McAllister
Journal: J Pharmacol Exp Ther Date: 1967-09 Impact factor: 4.030

3. Enhancement of the hepatotoxicity of trichloroethylene by inducers of drug metabolism.

Authors: G P Carlson
Journal: Res Commun Chem Pathol Pharmacol Date: 1974-03

4. Interaction of modifiers of hepatic microsomal drug metabolism and the inhalation toxicity of 1,1-dichloroethylene.

Authors: G P Carlson; G C Fuller
Journal: Res Commun Chem Pathol Pharmacol Date: 1972-11

5. Biochemical effects of 1,1-dichloroethylene in rats: comparison with carbon tetrachloride and 1,2-dichloroethylene.

Authors: L J Jenkins; M J Trabulus; S D Murphy
Journal: Toxicol Appl Pharmacol Date: 1972-11 Impact factor: 4.219

6. Acute hepatic injury by vinyl chloride in rats pretreated with phenobarbital.

Authors: R J Jaeger; E S Reynolds; R B Conolly; M T Moslen; S Szabo; S D Murphy
Journal: Nature Date: 1974-12-20 Impact factor: 49.962

7. Effect of carbon tetrachloride on induction of liver enzymes by acute stress or corticosterone.

Authors: S D Murphy; S Malley
Journal: Toxicol Appl Pharmacol Date: 1969-07 Impact factor: 4.219

Review 8. Cytochrome P-450 and its role in drug metabolism.

Authors: J R Gillette; D C Davis; H A Sasame
Journal: Annu Rev Pharmacol Date: 1972 Impact factor: 13.820

9. Effect of 18 hr fast and glutathione depletion on 1,1-dichloroethylene-induced hepatotoxicity and lethality in rats.

Authors: R J Jaeger; R B Conolly; S D Murphy
Journal: Exp Mol Pathol Date: 1974-04 Impact factor: 3.362

Review 10. Biotransformation of trichloroethylene.

Authors: J M Kelley; B R Brown
Journal: Int Anesthesiol Clin Date: 1974

11 in total

1. Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases.

Authors: H Bartsch; C Malaveille; A Barbin; G Planche
Journal: Arch Toxicol Date: 1979-02-23 Impact factor: 5.153

2. Uptake and hepatotoxicity of 1,1-dichloroethylene by the isolated blood-perfused rat liver.

Authors: D Reichert; D Henschler
Journal: Int Arch Occup Environ Health Date: 1978-05-12 Impact factor: 3.015

3. Cutaneous leishmaniasis. Ultrastructural study of 3 cases.

Authors: M Sandbank
Journal: Arch Dermatol Res Date: 1976-12-15 Impact factor: 3.017

4. Histochemical and immunocytochemical evidence of early, selective bile canaliculi injury after 1,1-dichloroethylene in rats.

Authors: M T Moslen; H A Dunsford; C Karnasuta; P Chieco; M F Kanz
Journal: Am J Pathol Date: 1989-05 Impact factor: 4.307

5. 1,1-Dichloroethylene hepatotoxicity. Time course of GSH changes and biochemical aberrations.

Authors: E S Reynolds; M T Moslen; P J Boor; R J Jaeger
Journal: Am J Pathol Date: 1980-11 Impact factor: 4.307

6. Development of hepatic angiosarcoma in man induced by vinyl chloride, thorotrast, and arsenic. Comparison with cases of unknown etiology.

Authors: H Popper; L B Thomas; N C Telles; H Falk; I J Selikoff
Journal: Am J Pathol Date: 1978-08 Impact factor: 4.307