Literature DB >> 11754607

A rapid and facile method for the dereplication of purified natural products.

J Bradshaw1, D Butina, A J Dunn, R H Green, M Hajek, M M Jones, J C Lindon, P J Sidebottom.   

Abstract

A new approach to the use of commercial databases for the dereplication of purified natural products has been developed. This is based on searching a text file that links each structure with its molecular weight and an exact count of the number of methyl, methylene, and methine groups it contains. Analysis of such a text file, constructed from a database containing more than 126,000 natural product structures, revealed that these data, readily measured using MS and NMR spectroscopy, are highly discriminating. The identification of an alkaloid and a sesquiterpene using this new approach is described.

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Year:  2001        PMID： 11754607     DOI： 10.1021/np010284g

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Dereplication, residual complexity, and rational naming: the case of the Actaea triterpenes.

Authors:  Feng Qiu; Ayano Imai; James B McAlpine; David C Lankin; Ian Burton; Tobias Karakach; Norman R Farnsworth; Shao-Nong Chen; Guido F Pauli
Journal:  J Nat Prod       Date:  2012-02-09       Impact factor: 4.050

2.  CYANOS: a data management system for natural product drug discovery efforts using cultured microorganisms.

Authors:  George E Chlipala; Aleksej Krunic; Shunyan Mo; Megan Sturdy; Jimmy Orjala
Journal:  J Chem Inf Model       Date:  2010-12-16       Impact factor: 4.956

Review 3.  Modern mass spectrometry for synthetic biology and structure-based discovery of natural products.

Authors:  Matthew T Henke; Neil L Kelleher
Journal:  Nat Prod Rep       Date:  2016-07-04       Impact factor: 13.423

Review 4.  A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.

Authors:  José C Aponte; Abraham J Vaisberg; Rosario Rojas; Michel Sauvain; Walter H Lewis; Gerardo Lamas; César Sarasara; Robert H Gilman; Gerald B Hammond
Journal:  J Nat Prod       Date:  2009-03-27       Impact factor: 4.050

5.  Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes.

Authors:  Pengfei Xie; Ming Ma; Mostafa E Rateb; Khaled A Shaaban; Zhiguo Yu; Sheng-Xiong Huang; Li-Xing Zhao; Xiangcheng Zhu; Yijun Yan; Ryan M Peterson; Jeremy R Lohman; Dong Yang; Min Yin; Jeffrey D Rudolf; Yi Jiang; Yanwen Duan; Ben Shen
Journal:  J Nat Prod       Date:  2014-01-31       Impact factor: 4.050

6.  Hydrazine-Containing Heterocycle Cytochalasan Derivatives From Hydrazinolysis of Extracts of a Desert Soil-Derived Fungus Chaetomium madrasense 375.

Authors:  Qingfeng Guo; Jinhua Chen; Yuwei Ren; Zhenhua Yin; Juanjuan Zhang; Baocheng Yang; Xuewei Wang; Wenbing Yin; Wancun Zhang; Gang Ding; Lin Chen
Journal:  Front Chem       Date:  2021-04-21       Impact factor: 5.221

7.  A Machine Learning Bioinformatics Method to Predict Biological Activity from Biosynthetic Gene Clusters.

Authors:  Allison S Walker; Jon Clardy
Journal:  J Chem Inf Model       Date:  2021-05-27       Impact factor: 4.956
  7 in total

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