Literature DB >> 11753347

Designing drugs against heterogeneous targets.

Ernesto Freire1.   

Abstract

Mesh：

Substances：

Year:  2002        PMID： 11753347     DOI： 10.1038/nbt0102-15

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


× No keyword cloud information.
  9 in total

1.  Overcoming drug resistance in HIV-1 chemotherapy: the binding thermodynamics of Amprenavir and TMC-126 to wild-type and drug-resistant mutants of the HIV-1 protease.

Authors:  Hiroyasu Ohtaka; Adrian Velázquez-Campoy; Dong Xie; Ernesto Freire
Journal:  Protein Sci       Date:  2002-08       Impact factor: 6.725

2.  Evolvability is a selectable trait.

Authors:  David J Earl; Michael W Deem
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-02       Impact factor: 11.205

3.  Evolution and evolvability of proteins in the laboratory.

Authors:  Michael W Deem
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-15       Impact factor: 11.205

4.  Modulation of base-specific mutation and recombination rates enables functional adaptation within the context of the genetic code.

Authors:  Taison Tan; Leonard D Bogarad; Michael W Deem
Journal:  J Mol Evol       Date:  2004-09       Impact factor: 2.395

5.  Specificity in molecular design: a physical framework for probing the determinants of binding specificity and promiscuity in a biological environment.

Authors:  Mala L Radhakrishnan; Bruce Tidor
Journal:  J Phys Chem B       Date:  2007-11-03       Impact factor: 2.991

6.  Optimal drug cocktail design: methods for targeting molecular ensembles and insights from theoretical model systems.

Authors:  Mala L Radhakrishnan; Bruce Tidor
Journal:  J Chem Inf Model       Date:  2008-05-27       Impact factor: 4.956

7.  Novel method for probing the specificity binding profile of ligands: applications to HIV protease.

Authors:  Woody Sherman; Bruce Tidor
Journal:  Chem Biol Drug Des       Date:  2008-03-31       Impact factor: 2.817

8.  Core site-moiety maps reveal inhibitors and binding mechanisms of orthologous proteins by screening compound libraries.

Authors:  Kai-Cheng Hsu; Wen-Chi Cheng; Yen-Fu Chen; Hung-Jung Wang; Ling-Ting Li; Wen-Ching Wang; Jinn-Moon Yang
Journal:  PLoS One       Date:  2012-02-29       Impact factor: 3.240

9.  A look inside HIV resistance through retroviral protease interaction maps.

Authors:  Aleksejs Kontijevskis; Peteris Prusis; Ramona Petrovska; Sviatlana Yahorava; Felikss Mutulis; Ilze Mutule; Jan Komorowski; Jarl E S Wikberg
Journal:  PLoS Comput Biol       Date:  2007-01-24       Impact factor: 4.475
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.