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Literature DB >> 117504

Differential effects of methylphenidate and d-amphetamine on stereotyped behavior in the rat.

Abstract

Different equimolar doses of d-amphetamine and methylphenidate were compared for their potency in eliciting stereotyped behavior in rats. Although at lower doses d-amphetamine appeared more effective in causing stereotyped gnawing, repetitive body movements, and sniffing, at higher doses methylphenidate at certain times caused a greater incidence of gnawing than did d-amphetamine. Understanding these differences and comparing related biochemical correlates may lead to a better definition of mechanisms underlying psychostimulant effects.

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Year: 1979 PMID： 117504 DOI： 10.1007/bf00492220

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

23 in total

Differential effects of methylphenidate and d-amphetamine on stereotyped behavior in the rat.

1. Blockade by reserpine of methylphenidate-induced release of brain dopamine.

2. The substantia nigra and stereotyped behaviour.

3. Stereotyped and non-stereotyped behaviour in rats induced by various stimulant drugs.

4. Extrapyramidal and mesolimbic involvement with the stereotypic activity of D- and L-amphetamine.

5. Methylphenidate antagonism of haloperidol, interaction with cholinergic and anticholinergic drugs.

6. Antagonism of methylphenidate-induced stereotyped gnawing in mice.

7. Stereotyped activities produced by amphetamine in several animal species and man.

8. The involvement of dopaminergic systems with the stereotyped behaviour patterns induced by methylphenidate.

9. Catecholamine uptake by synaptosomes in homogenates of rat brain: stereospecificity in different areas.

10. Methylphenidate, dextroamphetamine, and levamfetamine. Effects on schizophrenic symptoms.

1. Acute dose-related differential effects of methylphenidate on murine cystometric parameters.

2. Low doses of methylphenidate (Ritalin) may alter the delay-of-reinforcement gradient.

3. Critical role of the embryonic mid-hindbrain organizer in the behavioral response to amphetamine and methylphenidate.