A topological account of chirality.

Graph invariants may differentiate structural isomers but are inappropriate to account for stereoisomerism and to distinguish between chiral structures. This work is an attempt to address this problem. A chiral function F satisfying condition F(D) = -F(L), where D and L denote enantiomers of the same structure, has been applied in combination with Randic's index (1)chi(v). The resulting index chi(c) was used to explain the variance in thin-layer chromatographic retention indices.(1)