O Y Gorlova1, M Kimmel, C Henschke. 1. Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Abstract
BACKGROUND: Results from the Mayo Lung Project (MLP), a randomized clinical trial for the early detection of lung carcinoma, were interpreted as proof that the early detection of lung carcinoma by chest X-ray does not reduce the mortality from this disease. Recent analysis of extended follow-up data from the MLP subjects found that after approximately 20 years there still was no apparent difference in lung carcinoma mortality between a study group and a control group. METHODS: To view this result within context, the authors utilized a previously published simulation model of the MLP, with parametric values that were estimated at the time of the original publication based on the data collected by the MLP. RESULTS: The model produced predictions of the extended follow-up statistics that were found to be consistent with the data published in the prior study. The authors believe this provides long-term validation for the model. Conversely, the same model demonstrated that had the study subjects been screened annually for the extended follow-up period, the difference in mortality would be noticeable, even with the low sensitivity of chest X-ray detection. CONCLUSIONS: The results of current study strongly suggest that long-term screening with chest X-ray results in a reduction in lung carcinoma mortality. The limited extent of this benefit is the result of the low sensitivity of chest X-ray as a screening tool. Copyright 2001 American Cancer Society.
RCT Entities:
BACKGROUND: Results from the Mayo Lung Project (MLP), a randomized clinical trial for the early detection of lung carcinoma, were interpreted as proof that the early detection of lung carcinoma by chest X-ray does not reduce the mortality from this disease. Recent analysis of extended follow-up data from the MLP subjects found that after approximately 20 years there still was no apparent difference in lung carcinoma mortality between a study group and a control group. METHODS: To view this result within context, the authors utilized a previously published simulation model of the MLP, with parametric values that were estimated at the time of the original publication based on the data collected by the MLP. RESULTS: The model produced predictions of the extended follow-up statistics that were found to be consistent with the data published in the prior study. The authors believe this provides long-term validation for the model. Conversely, the same model demonstrated that had the study subjects been screened annually for the extended follow-up period, the difference in mortality would be noticeable, even with the low sensitivity of chest X-ray detection. CONCLUSIONS: The results of current study strongly suggest that long-term screening with chest X-ray results in a reduction in lung carcinoma mortality. The limited extent of this benefit is the result of the low sensitivity of chest X-ray as a screening tool. Copyright 2001 American Cancer Society.
Authors: Gavin J Gordon; Levi A Deters; Matthew D Nitz; Barry C Lieberman; Beow Y Yeap; Raphael Bueno Journal: J Thorac Cardiovasc Surg Date: 2006-09 Impact factor: 5.209
Authors: Xing Chen; Ivan P Gorlov; Kelly W Merriman; Shih-Feng Weng; Millennia Foy; Gwendolyn Keener; Christopher I Amos; Margaret R Spitz; Marek Kimmel; Olga Y Gorlova Journal: Lung Cancer Date: 2011-06-08 Impact factor: 5.705