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Literature DB >> 11743029

The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic.

G Paglini¹, L Peris, J Diez-Guerra, S Quiroga, A Cáceres.

Abstract

We show here that an active Cdk5-p35 kinase is present in Golgi membranes, where it associates with a detergent-insoluble fraction containing actin. In addition, Cdk5-p35-dependent phosphorylation of alpha-PAK immunoreactive protein species was detected in Golgi membranes, as well as an interaction with the small GTPase, Cdc42. Moreover, antisense oligonucleotide suppression of Cdk5 or p35 in young cultured neurons, as well as inhibition of Cdk5 activity with olomoucine, blocks the formation of membrane vesicles from the Golgi apparatus. Taken together, these results show a novel subcellular localization of this kinase and suggest a role for Cdk5-p35 in membrane traffic during neuronal process outgrowth.

Entities: Chemical Gene

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Year: 2001 PMID： 11743029 PMCID： PMC1084168 DOI： 10.1093/embo-reports/kve250

Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807

25 in total

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2. The role of the Cdk5--p35 kinase in neuronal development.

Authors: G Paglini; A Cáceres
Journal: Eur J Biochem Date: 2001-03

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Authors: K W Moremen; O Touster
Journal: J Biol Chem Date: 1986-08-15 Impact factor: 5.157

Review 4. A decade of CDK5.

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Journal: Nat Rev Mol Cell Biol Date: 2001-10 Impact factor: 94.444

5. PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.

Authors: A Abo; J Qu; M S Cammarano; C Dan; A Fritsch; V Baud; B Belisle; A Minden
Journal: EMBO J Date: 1998-11-16 Impact factor: 11.598

6. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.

Authors: L H Tsai; I Delalle; V S Caviness; T Chae; E Harlow
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7. A brain-specific activator of cyclin-dependent kinase 5.

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10. p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton.

Authors: S Humbert; R Dhavan; L Tsai
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26 in total

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5. Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis.

Authors: Niranjana D Amin; Ya-Li Zheng; Sashi Kesavapany; Jyotshnabala Kanungo; Tad Guszczynski; Ram K Sihag; Parvathi Rudrabhatla; Wayne Albers; Philip Grant; Harish C Pant
Journal: J Neurosci Date: 2008-04-02 Impact factor: 6.167

6. Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy.

Authors: Deepali Bhandari; Inmaculada Lopez-Sanchez; Andrew To; I-Chung Lo; Nicolas Aznar; Anthony Leyme; Vijay Gupta; Ingrid Niesman; Adam L Maddox; Mikel Garcia-Marcos; Marilyn G Farquhar; Pradipta Ghosh
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