Literature DB >> 11740936

PIP3, PIP2, and cell movement--similar messages, different meanings?

R H Insall1, O D Weiner.   

Abstract

The inositol lipids PI(4,5)P(2) and PI(3,4,5)P(3) are important regulators of actin polymerization, but their different temporal and spatial dynamics suggest that they perform separate roles. PI(3,4,5)P(3) seems to act as an instructive second messenger, inducing local actin polymerization. PI(4,5)P(2) appears to be present at too high a concentration and homogeneous a distribution to fulfil a similar role. Instead, we suggest that PI(4,5)P(2) acts permissively, restricting new actin polymerization to the region of the plasma membrane.

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Year:  2001        PMID： 11740936      PMCID： PMC2819114          DOI： 10.1016/s1534-5807(01)00086-7

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  24 in total

1.  The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C.

Authors:  M P Derman; A Toker; J H Hartwig; K Spokes; J R Falck; C S Chen; L C Cantley; L G Cantley
Journal:  J Biol Chem       Date:  1997-03-07       Impact factor: 5.157

2.  G protein signaling events are activated at the leading edge of chemotactic cells.

Authors:  C A Parent; B J Blacklock; W M Froehlich; D B Murphy; P N Devreotes
Journal:  Cell       Date:  1998-10-02       Impact factor: 41.582

3.  The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils.

Authors:  V Niggli; H Keller
Journal:  Eur J Pharmacol       Date:  1997-09-17       Impact factor: 4.432

Review 4.  Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

Authors:  L R Stephens; T R Jackson; P T Hawkins
Journal:  Biochim Biophys Acta       Date:  1993-10-07

5.  Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling.

Authors:  S Wennström; P Hawkins; F Cooke; K Hara; K Yonezawa; M Kasuga; T Jackson; L Claesson-Welsh; L Stephens
Journal:  Curr Biol       Date:  1994-05-01       Impact factor: 10.834

6.  Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav.

Authors:  J Han; K Luby-Phelps; B Das; X Shu; Y Xia; R D Mosteller; U M Krishna; J R Falck; M A White; D Broek
Journal:  Science       Date:  1998-01-23       Impact factor: 47.728

7.  Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

Authors:  A S Nimnual; B A Yatsula; D Bar-Sagi
Journal:  Science       Date:  1998-01-23       Impact factor: 47.728

8.  Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils.

Authors:  L R Stephens; K T Hughes; R F Irvine
Journal:  Nature       Date:  1991-05-02       Impact factor: 49.962

9.  Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets.

Authors:  J H Hartwig; G M Bokoch; C L Carpenter; P A Janmey; L A Taylor; A Toker; T P Stossel
Journal:  Cell       Date:  1995-08-25       Impact factor: 41.582

10.  Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation.

Authors:  T J Kovacsovics; C Bachelot; A Toker; C J Vlahos; B Duckworth; L C Cantley; J H Hartwig
Journal:  J Biol Chem       Date:  1995-05-12       Impact factor: 5.157
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  86 in total

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Journal:  Biochemistry       Date:  2011-10-19       Impact factor: 3.162

Review 2.  Understanding eukaryotic chemotaxis: a pseudopod-centred view.

Authors:  Robert H Insall
Journal:  Nat Rev Mol Cell Biol       Date:  2010-05-06       Impact factor: 94.444

Review 3.  The regulation of vesicle trafficking by small GTPases and phospholipids during pollen tube growth.

Authors:  Yan Zhang; Sheila McCormick
Journal:  Sex Plant Reprod       Date:  2009-11-07

4.  Myo1c binds phosphoinositides through a putative pleckstrin homology domain.

Authors:  David E Hokanson; Joseph M Laakso; Tianming Lin; David Sept; E Michael Ostap
Journal:  Mol Biol Cell       Date:  2006-09-13       Impact factor: 4.138

5.  Distinguishing modes of eukaryotic gradient sensing.

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Journal:  Biophys J       Date:  2005-08-05       Impact factor: 4.033

Review 6.  Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools.

Authors:  Megan Santarius; Chang Ho Lee; Richard A Anderson
Journal:  Biochem J       Date:  2006-08-15       Impact factor: 3.857

Review 7.  Aging of the brain, neurotrophin signaling, and Alzheimer's disease: is IGF1-R the common culprit?

Authors:  Luigi Puglielli
Journal:  Neurobiol Aging       Date:  2007-02-20       Impact factor: 4.673

8.  Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells.

Authors:  Jianglan Liu; Xiaofeng Zuo; Peng Yue; Wei Guo
Journal:  Mol Biol Cell       Date:  2007-08-29       Impact factor: 4.138

9.  Localization of phosphatidylinositol (3,4,5)-trisphosphate to phagosomes in entamoeba histolytica achieved using glutathione S-transferase- and green fluorescent protein-tagged lipid biosensors.

Authors:  Yevgeniya A Byekova; Rhonda R Powell; Brenda H Welter; Lesly A Temesvari
Journal:  Infect Immun       Date:  2009-11-09       Impact factor: 3.441

10.  Spatial Segregation of Phosphatidylinositol 4,5-Bisphosphate (PIP(2)) Signaling in Immune Cell Functions.

Authors:  Corey M Johnson; William Rodgers
Journal:  Immunol Endocr Metab Agents Med Chem       Date:  2008-12-01
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