Literature DB >> 9438849

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

A S Nimnual1, B A Yatsula, D Bar-Sagi.   

Abstract

The Son of Sevenless (Sos) proteins control receptor-mediated activation of Ras by catalyzing the exchange of guanosine diphosphate for guanosine triphosphate on Ras. The NH2-terminal region of Sos contains a Dbl homology (DH) domain in tandem with a pleckstrin homology (PH) domain. In COS-1 cells, the DH domain of Sos stimulated guanine nucleotide exchange on Rac but not Cdc42 in vitro and in vivo. The tandem DH-PH domain of Sos (DH-PH-Sos) was defective in Rac activation but regained Rac stimulating activity when it was coexpressed with activated Ras. Ras-mediated activation of DH-PH-Sos did not require activation of mitogen-activated protein kinase but it was dependent on activation of phosphoinositide 3-kinase. These results reveal a potential mechanism for coupling of Ras and Rac signaling pathways.

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Year:  1998        PMID： 9438849     DOI： 10.1126/science.279.5350.560

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  132 in total

1.  Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation.

Authors:  I P Whitehead; Q T Lambert; J A Glaven; K Abe; K L Rossman; G M Mahon; J M Trzaskos; R Kay; S L Campbell; C J Der
Journal:  Mol Cell Biol       Date:  1999-11       Impact factor: 4.272

2.  The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain.

Authors:  X K Tong; N K Hussain; E de Heuvel; A Kurakin; E Abi-Jaoude; C C Quinn; M F Olson; R Marais; D Baranes; B K Kay; P S McPherson
Journal:  EMBO J       Date:  2000-03-15       Impact factor: 11.598

Review 3.  Signaling from Ras to Rac and beyond: not just a matter of GEFs.

Authors:  G Scita; P Tenca; E Frittoli; A Tocchetti; M Innocenti; G Giardina; P P Di Fiore
Journal:  EMBO J       Date:  2000-06-01       Impact factor: 11.598

Review 4.  Regulatory and signaling properties of the Vav family.

Authors:  X R Bustelo
Journal:  Mol Cell Biol       Date:  2000-03       Impact factor: 4.272

5.  Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth.

Authors:  T Goi; G Rusanescu; T Urano; L A Feig
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

Review 6.  Neurotrophins: roles in neuronal development and function.

Authors:  E J Huang; L F Reichardt
Journal:  Annu Rev Neurosci       Date:  2001       Impact factor: 12.449

7.  Opposing roles of the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in Ras-mediated downregulation of tropomyosin.

Authors:  Janiel M Shields; Heena Mehta; Kevin Pruitt; Channing J Der
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

8.  Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation.

Authors:  Michelle A Booden; Sharon L Campbell; Channing J Der
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

9.  Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

Authors:  T S Manetz; C Gonzalez-Espinosa; R Arudchandran; S Xirasagar; V Tybulewicz; J Rivera
Journal:  Mol Cell Biol       Date:  2001-06       Impact factor: 4.272

10.  A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.

Authors:  Christian E Rocheleau; Robyn M Howard; Alissa P Goldman; Mandy L Volk; Laura J Girard; Meera V Sundaram
Journal:  Genetics       Date:  2002-05       Impact factor: 4.562
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