Literature DB >> 11739837

Effects of estrogen replacement therapy on human brain aging: an in vivo 1H MRS study.

D M Robertson1, T van Amelsvoort, E Daly, A Simmons, M Whitehead, R G Morris, K C Murphy, D G Murphy.   

Abstract

Estrogen replacement therapy (ERT) may preserve cognitive function in postmenopausal women, but the mechanism is unknown. Thus, the authors studied aging of parietal lobe and hippocampus using proton MR spectroscopy. ERT naïve postmenopausal women had a significant increase in choline-containing compounds (Cho) compared to long-term ERT users and young women. Cho reflects increased neuronal/glial membrane turnover. Thus, ERT's "neuroprotective" effect may include modulating the effects of age on neural integrity in brain regions involved in cognitive function.

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Year:  2001        PMID： 11739837     DOI： 10.1212/wnl.57.11.2114

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  8 in total

Review 1.  Aging of brain: role of estrogen.

Authors:  M K Thakur; P K Sharma
Journal:  Neurochem Res       Date:  2006-10-24       Impact factor: 3.996

2.  Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using 1H magnetic resonance spectroscopy at 7 T.

Authors:  Małgorzata Marjańska; J Riley McCarten; James Hodges; Laura S Hemmy; Andrea Grant; Dinesh K Deelchand; Melissa Terpstra
Journal:  Neuroscience       Date:  2017-05-03       Impact factor: 3.590

3.  Diurnal changes in glutamate + glutamine levels of healthy young adults assessed by proton magnetic resonance spectroscopy.

Authors:  Carina Volk; Valeria Jaramillo; Renato Merki; Ruth O'Gorman Tuura; Reto Huber
Journal:  Hum Brain Mapp       Date:  2018-06-08       Impact factor: 5.038

4.  Edited magnetic resonance spectroscopy detects an age-related decline in brain GABA levels.

Authors:  Fei Gao; Richard A E Edden; Muwei Li; Nicolaas A J Puts; Guangbin Wang; Cheng Liu; Bin Zhao; Huiquan Wang; Xue Bai; Chen Zhao; Xin Wang; Peter B Barker
Journal:  Neuroimage       Date:  2013-04-13       Impact factor: 6.556

5.  Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease.

Authors:  Madhav Thambisetty; Abdul Hye; Catherine Foy; Eileen Daly; Amanda Glover; Allison Cooper; Andrew Simmons; Declan Murphy; Simon Lovestone
Journal:  J Neurol       Date:  2008-08-01       Impact factor: 4.849

6.  Hippocampal glutamate-glutamine (Glx) in adults with Down syndrome: a preliminary study using in vivo proton magnetic resonance spectroscopy ((1)H MRS).

Authors:  Giles My Tan; Felix Beacher; Eileen Daly; Jamie Horder; Verinder Prasher; Maria-Luisa Hanney; Robin Morris; Simon Lovestone; Kieran C Murphy; Andrew Simmons; Declan Gm Murphy
Journal:  J Neurodev Disord       Date:  2014-11-27       Impact factor: 4.025

Review 7.  Functional and molecular neuroimaging of menopause and hormone replacement therapy.

Authors:  Erika Comasco; Vibe G Frokjaer; Inger Sundström-Poromaa
Journal:  Front Neurosci       Date:  2014-12-08       Impact factor: 4.677

8.  In Vivo Assessment of Neurodegeneration in Type C Niemann-Pick Disease by IDEAL-IQ.

Authors:  Ruo-Mi Guo; Qing-Ling Li; Zhong-Xing Luo; Wen Tang; Ju Jiao; Jin Wang; Zhuang Kang; Shao-Qiong Chen; Yong Zhang
Journal:  Korean J Radiol       Date:  2018-01-02       Impact factor: 3.500
  8 in total

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