Literature DB >> 11738970

Ion-channel assay technologies: quo vadis?

Jia Xu1, Xiaobo Wang, Brooks Ensign, Min Li, Lei Wu, Antonio Guia, Junquan Xu.   

Abstract

Although many existing methods are used to study the functions of ion channels and to screen lead compounds for important ion-channel targets, new technologies are being developed for improved performance. It is important to identify the advantages and disadvantages of each technology. In this review, we segment the ion-channel assay market according to distinguishable applications, and compare the needs of each market segment with the capabilities of different technologies in terms of multiple assay attributes. We further discuss the future directions in the development of ion-channel assays.

Year:  2001        PMID： 11738970     DOI： 10.1016/s1359-6446(01)02095-5

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  22 in total

1.  Whole cell patch clamp recording performed on a planar glass chip.

Authors:  Niels Fertig; Robert H Blick; Jan C Behrends
Journal:  Biophys J       Date:  2002-06       Impact factor: 4.033

2.  Imaging the activity and localization of single voltage-gated Ca(2+) channels by total internal reflection fluorescence microscopy.

Authors:  Angelo Demuro; Ian Parker
Journal:  Biophys J       Date:  2004-05       Impact factor: 4.033

3.  Profiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-à-go-go related gene potassium channels.

Authors:  Beiyan Zou; Haibo Yu; Joseph J Babcock; Pritam Chanda; Joel S Bader; Owen B McManus; Min Li
Journal:  Assay Drug Dev Technol       Date:  2010-12       Impact factor: 1.738

4.  A novel method for patch-clamp automation.

Authors:  D Vasilyev; T Merrill; A Iwanow; J Dunlop; M Bowlby
Journal:  Pflugers Arch       Date:  2006-04-05       Impact factor: 3.657

5.  Mammalian electrophysiology on a microfluidic platform.

Authors:  Cristian Ionescu-Zanetti; Robin M Shaw; Jeonggi Seo; Yuh-Nung Jan; Lily Y Jan; Luke P Lee
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-20       Impact factor: 11.205

Review 6.  Cell-based assays for high-throughput screening.

Authors:  W Frank An; Nicola Tolliday
Journal:  Mol Biotechnol       Date:  2010-06       Impact factor: 2.695

7.  Shaped apertures in photoresist films enhance the lifetime and mechanical stability of suspended lipid bilayers.

Authors:  Sumit Kalsi; Andrew M Powl; B A Wallace; Hywel Morgan; Maurits R R de Planque
Journal:  Biophys J       Date:  2014-04-15       Impact factor: 4.033

8.  Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions.

Authors:  Zhaobing Gao; Tangzhi Zhang; Meng Wu; Qiaojie Xiong; Haiyan Sun; Yinan Zhang; Liansuo Zu; Wei Wang; Min Li
Journal:  J Biol Chem       Date:  2010-06-28       Impact factor: 5.157

9.  An air-molding technique for fabricating PDMS planar patch-clamp electrodes.

Authors:  Kathryn G Klemic; James F Klemic; Fred J Sigworth
Journal:  Pflugers Arch       Date:  2004-12-01       Impact factor: 3.657

10.  Microfabricated teflon membranes for low-noise recordings of ion channels in planar lipid bilayers.

Authors:  Michael Mayer; Jennah K Kriebel; Magdalena T Tosteson; George M Whitesides
Journal:  Biophys J       Date:  2003-10       Impact factor: 4.033
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