Literature DB >> 11730948

Immunoglobulin isotypes reveal a predominant role of type 1 immunity in multiple sclerosis.

B Greve1, C G Magnusson, A Melms, R Weissert.   

Abstract

IgG, its subclasses and IgE concentrations were measured in cerebrospinal fluid (CSF) and serum of multiple sclerosis (MS) patients and matched controls as surrogate markers for type 1 and type 2 immunity. IgE indices were significantly reduced in MS patients compared to controls. In contrast, IgG1 was elevated in CSF of MS patients and elevated indices indicated intrathecal synthesis. Because isotype switching to IgE and IgG4 is driven by type 2 immunity and occurrence of IgG1 has previously been found in type 1 immunity-dominated diseases, the results underscore a role of type 1 immunity in MS.

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Year:  2001        PMID： 11730948     DOI： 10.1016/s0165-5728(01)00436-2

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  12 in total

1.  Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.

Authors:  Dorothea Buck; Eva Albrecht; Muhammad Aslam; An Goris; Natalie Hauenstein; Angela Jochim; Sabine Cepok; Verena Grummel; Bénédicte Dubois; Achim Berthele; Peter Lichtner; Christian Gieger; Juliane Winkelmann; Bernhard Hemmer
Journal:  Ann Neurol       Date:  2012-12-07       Impact factor: 10.422

2.  Relationship between serum levels of IL-18 and IgG1 in patients with primary Sjögren's syndrome, rheumatoid arthritis and healthy controls.

Authors:  P Eriksson; C Andersson; C Ekerfelt; J Ernerudh; T Skogh
Journal:  Clin Exp Immunol       Date:  2004-09       Impact factor: 4.330

3.  Survey of naturally occurring CD4+ T cell responses against NY-ESO-1 in cancer patients: correlation with antibody responses.

Authors:  Sacha Gnjatic; Djordje Atanackovic; Elke Jäger; Mitsutoshi Matsuo; Annamalai Selvakumar; Nasser K Altorki; Robert G Maki; Bo Dupont; Gerd Ritter; Yao-Tseng Chen; Alexander Knuth; Lloyd J Old
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-09       Impact factor: 11.205

Review 4.  T helper cell polarization in healthy people: implications for cardiovascular disease.

Authors:  Nels C Olson; Reem Sallam; Margaret F Doyle; Russell P Tracy; Sally A Huber
Journal:  J Cardiovasc Transl Res       Date:  2013-08-07       Impact factor: 4.132

Review 5.  [New understanding of the immunopathogenesis of multiple sclerosis].

Authors:  B Rosche; B Kieseier; H-P Hartung; B Hemmer
Journal:  Nervenarzt       Date:  2003-08       Impact factor: 1.214

6.  Higher Serum Immunoglobulin G3 Levels May Predict the Development of Multiple Sclerosis in Individuals With Clinically Isolated Syndrome.

Authors:  Stephanie Trend; Anderson P Jones; Lilian Cha; Scott N Byrne; Sian Geldenhuys; Marzena J Fabis-Pedrini; William M Carroll; Judith M Cole; David R Booth; Robyn M Lucas; Allan G Kermode; Martyn A French; Prue H Hart
Journal:  Front Immunol       Date:  2018-07-13       Impact factor: 7.561

7.  CSF parameters associated with early MRI activity in patients with MS.

Authors:  Ana Klein; Rebecca C Selter; Alexander Hapfelmeier; Achim Berthele; Bertram Müller-Myhsok; Viola Pongratz; Christiane Gasperi; Claus Zimmer; Mark Mühlau; Bernhard Hemmer
Journal:  Neurol Neuroimmunol Neuroinflamm       Date:  2019-05-30

Review 8.  Compartmentalized intrathecal immunoglobulin synthesis during HIV infection - a model of chronic CNS inflammation?

Authors:  Mickael Bonnan; Bruno Barroso; Stéphanie Demasles; Elsa Krim; Raluca Marasescu; Marie Miquel
Journal:  J Neuroimmunol       Date:  2015-05-16       Impact factor: 3.478

Review 9.  Pathogenesis of autoimmune demyelination: from multiple sclerosis to neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody-associated disease.

Authors:  Joseph A Lopez; Martina Denkova; Sudarshini Ramanathan; Russell C Dale; Fabienne Brilot
Journal:  Clin Transl Immunology       Date:  2021-07-26

10.  Oligoclonal IgG antibodies in multiple sclerosis target patient-specific peptides.

Authors:  Michael Graner; Tiffany Pointon; Sean Manton; Miyoko Green; Kathryn Dennison; Mollie Davis; Gino Braiotta; Julia Craft; Taylor Edwards; Bailey Polonsky; Anthony Fringuello; Timothy Vollmer; Xiaoli Yu
Journal:  PLoS One       Date:  2020-02-21       Impact factor: 3.240
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