| Literature DB >> 11720582 |
A B Smith1, Y S Cho, H Ishiyama.
Abstract
In this, the second of two Letters, we describe an effective assembly of (+)-4, an eastern hemisphere subtarget comprising the FGH rings of (+)-nodulisporic acid A (1) (17 steps, 9% overall yield). Central to the synthesis is a Koga three-component conjugate addition-alkylation sequence which secures the trans orientation of the vicinal quaternary methyl groups. [reaction: see text]Entities:
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Year: 2001 PMID： 11720582 DOI： 10.1021/ol016888t
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005