Literature DB >> 1171651

Differential potentiation by nystatin of the effect of antibiotics on yeast and mammalian cells.

A Aszalos.   

Abstract

The effect of the polyene antibiotic nystatin, used in combination with several other antibiotics, on the membranes of Candida albicans SC#8169 (yeast) cells and of Chinese hamster ovary and 3T3 (mammalian) cells was investigated. It was concluded from determinations of the viability of the yeast cells and from measurements of deoxyribonucleic acid synthesis by the mammalian cells that nystatin acts synergistically with several antibiotics on yeast cells, but not on CHO and 3T3 cells. This selective action of nystatin may prove useful in chemotherapy.

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Year:  1975        PMID： 1171651      PMCID： PMC429222          DOI： 10.1128/AAC.7.6.754

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Potentiation of rifampicin, rifampicin analogs, and tetracycline against animal cells by amphotericin B and polymyxin B.

Authors:  G Medoff; C N Kwan; D Schlessinger; G S Kobayashi
Journal:  Cancer Res       Date:  1973-06       Impact factor: 12.701

2.  Potentiation of 5-fluorouracil, chromomycin A3, and bleomycin by amphotericin B or polymyxin B in transformed fibroblastic cells.

Authors:  M Kuwano; T Kamiya; H Endo; S Komiyama
Journal:  Antimicrob Agents Chemother       Date:  1973-05       Impact factor: 5.191

3.  Drug-induced alterations in the ultrastructural organization of Histoplasma capsulatum and Blastomyces dermatitidis.

Authors:  J W Lane; R G Garrison; D R Johnson
Journal:  Mycopathol Mycol Appl       Date:  1972-12-15

4.  Transport of amino acids by confluent and nonconfluent 3T3 and polyoma virus-transformed 3T3 cells growing on glass cover slips.

Authors:  D O Foster; A B Pardee
Journal:  J Biol Chem       Date:  1969-05-25       Impact factor: 5.157

5.  Permeability control in animal cells by polyenes: a possibility.

Authors:  G Medoff; C N Kwan; D Schlessinger; G S Kobayashi
Journal:  Antimicrob Agents Chemother       Date:  1973-03       Impact factor: 5.191

6.  Transport changes in synchronously growing CHO and L cells.

Authors:  G Sander; A B Pardee
Journal:  J Cell Physiol       Date:  1972-10       Impact factor: 6.384

7.  Selective membrane toxicity of the polyene antibiotics: studies on natural membranes.

Authors:  C C Hsuchen; D S Feingold
Journal:  Antimicrob Agents Chemother       Date:  1973-09       Impact factor: 5.191

8.  Amphotericin B potentiation of rifampicin as an antifungal agent against the yeast phase of Histoplasma capsulatum.

Authors:  G S Kobbayashi; G Medoff; D Schlessinger; C N Kwan; W E Musser
Journal:  Science       Date:  1972-08-25       Impact factor: 47.728

9.  Potentiation of rifampicin and 5-fluorocytosine as antifungal antibiotics by amphotericin B (yeast-membrane permeability-ribosomal RNA-eukaryotic cell-synergism).

Authors:  G Medoff; G S Kobayashi; C N Kwan; D Schlessinger; P Venkov
Journal:  Proc Natl Acad Sci U S A       Date:  1972-01       Impact factor: 11.205

10.  Effects of rifamycin derivatives, alone and in combination with amphotericin B, against Histoplasma capsulatum.

Authors:  G S Kobayashi; S S Cheung; D Schlessinger; G Medoff
Journal:  Antimicrob Agents Chemother       Date:  1974-01       Impact factor: 5.191
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  1 in total

1.  Classification of polyene antibiotics according to chemical structure and biological effects.

Authors:  J Kotler-Brajtburg; G Medoff; G S Kobayashi; S Boggs; D Schlessinger; R C Pandey; K L Rinehart
Journal:  Antimicrob Agents Chemother       Date:  1979-05       Impact factor: 5.191
  1 in total

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