| Literature DB >> 11710992 |
M Giorelli1, P Livrea, G Defazio, F Ricchiuti, E Pagano, M Trojano.
Abstract
Recently, mRNA encoding soluble isoforms of CD28 and CTLA-4 have been described in human lymphocytes. We demonstrate that interferon-beta1a (IFN-beta1a) can enhance the expression of these transcripts in human mononuclear cells. Because soluble CD28 and CTLA-4 molecules might affect T cell activation, our findings suggest an additional means whereby IFN-beta therapy might exert its immunomodulatory effects in multiple sclerosis (MS).Entities:
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Year: 2001 PMID： 11710992 DOI： 10.1089/107999001753238042
Source DB: PubMed Journal: J Interferon Cytokine Res ISSN： 1079-9907 Impact factor: 2.607