Literature DB >> 17408842

Post-transcriptional control of the interferon system.

Khalid S A Khabar1, Howard A Young.   

Abstract

The interferon (IFN) system is a well-controlled network of signaling, transcriptional, and post-transcriptional processes that orchestrate host defense against microbes. The IFN response comprises a multi-array of IFN-stimulated gene products that mediate a variety of biological processes designed to control infection and regulate specific immune responses. In this review, we focus on post-transcriptional mechanisms of gene regulation that occur during the course of IFN induction and during the response of cells to IFN. Post-transcriptional mechanisms involve different levels of regulation such as mRNA stability, alternative splicing, and translation. Such controls offer a fine tuning mechanism for efficient and rapid response and as a negative feedback control in IFN biosynthesis and response.

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Year:  2007        PMID： 17408842      PMCID： PMC1994070          DOI： 10.1016/j.biochi.2007.02.008

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  86 in total

1.  ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins.

Authors:  T Bakheet; M Frevel; B R Williams; W Greer; K S Khabar
Journal:  Nucleic Acids Res       Date:  2001-01-01       Impact factor: 16.971

2.  IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells: differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12.

Authors:  S Matikainen; A Paananen; M Miettinen; M Kurimoto; T Timonen; I Julkunen; T Sareneva
Journal:  Eur J Immunol       Date:  2001-07       Impact factor: 5.532

3.  Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR.

Authors:  S Li; A E Koromilas
Journal:  J Biol Chem       Date:  2001-02-05       Impact factor: 5.157

4.  IFN-beta inhibits the ability of T lymphocytes to induce TNF-alpha and IL-1beta production in monocytes upon direct cell-cell contact.

Authors:  F Jungo; J M Dayer; C Modoux; N Hyka; D Burger
Journal:  Cytokine       Date:  2001-06-07       Impact factor: 3.861

Review 5.  Functional classification of interferon-stimulated genes identified using microarrays.

Authors:  M J de Veer; M Holko; M Frevel; E Walker; S Der; J M Paranjape; R H Silverman; B R Williams
Journal:  J Leukoc Biol       Date:  2001-06       Impact factor: 4.962

6.  Functional characterization of interferon regulatory factor 3a (IRF-3a), an alternative splice isoform of IRF-3.

Authors:  A Y Karpova; L V Ronco; P M Howley
Journal:  Mol Cell Biol       Date:  2001-07       Impact factor: 4.272

7.  Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway.

Authors:  E Carballo; H Cao; W S Lai; E A Kennington; D Campbell; P J Blackshear
Journal:  J Biol Chem       Date:  2001-09-06       Impact factor: 5.157

8.  Bryostatin-1 and IL-2 synergize to induce IFN-gamma expression in human peripheral blood T cells: implications for cancer immunotherapy.

Authors:  R E Curiel; C S Garcia; L Farooq; M F Aguero; I Espinoza-Delgado
Journal:  J Immunol       Date:  2001-11-01       Impact factor: 5.422

Review 9.  Antiviral actions of interferons.

Authors:  C E Samuel
Journal:  Clin Microbiol Rev       Date:  2001-10       Impact factor: 26.132

10.  Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response.

Authors:  S J Polyak; K S Khabar; D M Paschal; H J Ezelle; G Duverlie; G N Barber; D E Levy; N Mukaida; D R Gretch
Journal:  J Virol       Date:  2001-07       Impact factor: 5.103
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  38 in total

1.  Novel In Situ Hybridization and Multiplex Immunofluorescence Technology Combined With Whole-slide Digital Image Analysis in Kidney Transplantation.

Authors:  Henrik Junger; Dejan Dobi; Adeline Chen; Linda Lee; Joshua J Vasquez; Qizhi Tang; Zoltan G Laszik
Journal:  J Histochem Cytochem       Date:  2020-07-01       Impact factor: 2.479

2.  Post-transcriptional control of cytokine gene expression in health and disease.

Authors:  Khalid S A Khabar
Journal:  J Interferon Cytokine Res       Date:  2014-02-19       Impact factor: 2.607

Review 3.  Post-transcriptional regulation of cytokine signaling by AU-rich and GU-rich elements.

Authors:  Irina Vlasova-St Louis; Paul R Bohjanen
Journal:  J Interferon Cytokine Res       Date:  2014-04       Impact factor: 2.607

4.  Stimulation of mesenchymal stromal cells (MSCs) via TLR3 reveals a novel mechanism of autocrine priming.

Authors:  Claudia A Dumitru; Hatim Hemeda; Mark Jakob; Stephan Lang; Sven Brandau
Journal:  FASEB J       Date:  2014-05-15       Impact factor: 5.191

5.  Human Cytokinome Analysis for Interferon Response.

Authors:  Suhad Al-Yahya; Linah Mahmoud; Fahad Al-Zoghaibi; Abdullah Al-Tuhami; Haithem Amer; Fahad N Almajhdi; Stephen J Polyak; Khalid S A Khabar
Journal:  J Virol       Date:  2015-04-29       Impact factor: 5.103

6.  Interferon-β therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever.

Authors:  Lauren M Smith; Lisa E Hensley; Thomas W Geisbert; Joshua Johnson; Andrea Stossel; Anna Honko; Judy Y Yen; Joan Geisbert; Jason Paragas; Elizabeth Fritz; Gene Olinger; Howard A Young; Kathleen H Rubins; Christopher L Karp
Journal:  J Infect Dis       Date:  2012-12-18       Impact factor: 5.226

7.  Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes.

Authors:  Claus Vogl; Thomas Flatt; Bernd Fuhrmann; Elisabeth Hofmann; Barbara Wallner; Rita Stiefvater; Pavel Kovarik; Birgit Strobl; Mathias Müller
Journal:  BMC Genomics       Date:  2010-03-25       Impact factor: 3.969

Review 8.  Regulation of type I interferon responses.

Authors:  Lionel B Ivashkiv; Laura T Donlin
Journal:  Nat Rev Immunol       Date:  2014-01       Impact factor: 53.106

9.  TNF-alpha stimulation inhibits siRNA-mediated RNA interference through a mechanism involving poly-(A) tail stabilization.

Authors:  Johann Mols; Arjen van den Berg; Motoyuki Otsuka; Min Zheng; Jianming Chen; Jiahuai Han
Journal:  Biochim Biophys Acta       Date:  2008-04-01

10.  Endoribonuclease L (RNase L) regulates the myogenic and adipogenic potential of myogenic cells.

Authors:  Tamim Salehzada; Linda Cambier; Nga Vu Thi; Laurent Manchon; Laëtitia Regnier; Catherine Bisbal
Journal:  PLoS One       Date:  2009-10-23       Impact factor: 3.240
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