Literature DB >> 11710734

Natural products in anticancer therapy.

A B da Rocha1, R M Lopes, G Schwartsmann.   

Abstract

Many pharmaceutical agents have been discovered by screening natural products from plants, animals, marine organisms and microorganisms. Vincristine, irinotecan, etoposide and paclitaxel are examples of plant-derived compounds that are being employed in cancer treatment, and dactinomycin, bleomycin and doxorubicin are anticancer agents derived from microbial sources. Citarabine is an example of an anticancer agent originating from a marine source. Other agents originating from marine sources are bryostatin-1, aplidine, dolastatin 10 and ET-743, which have recently entered phase I and II clinical trials.

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Year:  2001        PMID： 11710734     DOI： 10.1016/s1471-4892(01)00063-7

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  113 in total

1.  Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro.

Authors:  Yi-ming Ma; Wei Han; Jia Li; Li-hong Hu; Yu-bo Zhou
Journal:  Acta Pharmacol Sin       Date:  2015-03-23       Impact factor: 6.150

2.  Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death.

Authors:  Hong Ri Jin; Charles H Du; Chong-Zhi Wang; Chun-Su Yuan; Wei Du
Journal:  Phytother Res       Date:  2018-12-09       Impact factor: 5.878

3.  Induction of apoptosis and reversal of permeability glycoprotein-mediated multidrug resistance of MCF-7/ADM by ginsenoside Rh2.

Authors:  Hui Zhang; Jian Gong; Huilai Zhang; Di Kong
Journal:  Int J Clin Exp Pathol       Date:  2015-05-01

4.  Antitumor activity of the Ailanthus altissima bark phytochemical ailanthone against breast cancer MCF-7 cells.

Authors:  Ruxing Wang; Yanjie Lu; Hong Li; Lixin Sun; Ning Yang; Mingzhen Zhao; Manli Zhang; Qingwen Shi
Journal:  Oncol Lett       Date:  2018-02-13       Impact factor: 2.967

5.  Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies.

Authors:  Guy Lahat; Quan-Sheng Zhu; Kai-Lieh Huang; Suizhao Wang; Svetlana Bolshakov; Jeffery Liu; Keila Torres; Robert R Langley; Alexander J Lazar; Mien Chie Hung; Dina Lev
Journal:  PLoS One       Date:  2010-04-16       Impact factor: 3.240

6.  Primary screening of the bioactivity of brackishwater cyanobacteria: toxicity of crude extracts to Artemia salina larvae and Paracentrotus lividus embryos.

Authors:  Viviana R Lopes; Nuria Fernández; Rosário F Martins; Vitor Vasconcelos
Journal:  Mar Drugs       Date:  2010-03-05       Impact factor: 5.118

7.  Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential.

Authors:  Soumya J Koppikar; Amit S Choudhari; Snehal A Suryavanshi; Shweta Kumari; Samit Chattopadhyay; Ruchika Kaul-Ghanekar
Journal:  BMC Cancer       Date:  2010-05-18       Impact factor: 4.430

Review 8.  Marine antitumor drugs: status, shortfalls and strategies.

Authors:  Ira Bhatnagar; Se-Kwon Kim
Journal:  Mar Drugs       Date:  2010-10-15       Impact factor: 5.118

9.  Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.

Authors:  Walid Fayad; Mårten Fryknäs; Slavica Brnjic; Maria Hägg Olofsson; Rolf Larsson; Stig Linder
Journal:  PLoS One       Date:  2009-10-02       Impact factor: 3.240

10.  Perspectives on using physcomitrella patens as an alternative production platform for thapsigargin and other terpenoid drug candidates.

Authors:  Henrik Toft Simonsen; Damian Paul Drew; Christina Lunde
Journal:  Perspect Medicin Chem       Date:  2009-03-04
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