Literature DB >> 11709365

Mechanism of action of the des-F(6) quinolone BMS-284756 measured by supercoiling inhibition and cleavable complex assays.

P Wu1, L E Lawrence, K L Denbleyker, J F Barrett.   

Abstract

BMS-284756 (T-3811ME), a novel des-F(6) quinolone, was tested in the supercoiling inhibition and cleavable complex assays against Escherichia coli DNA gyrase, a target of quinolones. The results suggest that BMS-284756 has the same mechanism of action against DNA gyrase as other quinolones and a similar level of potency.

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Year:  2001        PMID： 11709365      PMCID： PMC90894          DOI： 10.1128/AAC.45.12.3660-3662.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  In vitro and in vivo antimicrobial activities of T-3811ME, a novel des-F(6)-quinolone.

Authors:  M Takahata; J Mitsuyama; Y Yamashiro; M Yonezawa; H Araki; Y Todo; S Minami; Y Watanabe; H Narita
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

2.  Significance of the methyl group on the oxazine ring of ofloxacin derivatives in the inhibition of bacterial and mammalian type II topoisomerases.

Authors:  K Hoshino; K Sato; K Akahane; A Yoshida; I Hayakawa; M Sato; T Une; Y Osada
Journal:  Antimicrob Agents Chemother       Date:  1991-02       Impact factor: 5.191

Review 3.  DNA topoisomerases.

Authors:  J C Wang
Journal:  Annu Rev Biochem       Date:  1996       Impact factor: 23.643

Review 4.  DNA gyrase, topoisomerase IV, and the 4-quinolones.

Authors:  K Drlica; X Zhao
Journal:  Microbiol Mol Biol Rev       Date:  1997-09       Impact factor: 11.056

5.  DNA cleavage activities of Staphylococcus aureus gyrase and topoisomerase IV stimulated by quinolones and 2-pyridones.

Authors:  A Y Saiki; L L Shen; C M Chen; J Baranowski; C G Lerner
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

6.  Selection and genetic characterization of Streptococcus pneumoniae mutants resistant to the des-F(6) quinolone BMS-284756.

Authors:  S Hartman-Neumann; K DenBleyker; L A Pelosi; L E Lawrence; J F Barrett; T J Dougherty
Journal:  Antimicrob Agents Chemother       Date:  2001-10       Impact factor: 5.191

7.  Testing potential gyrase inhibitors of bacterial DNA gyrase: a comparison of the supercoiling inhibition assay and "cleavable complex" assay.

Authors:  J F Barrett; J I Bernstein; H M Krause; J J Hilliard; K A Ohemeng
Journal:  Anal Biochem       Date:  1993-10       Impact factor: 3.365

8.  The inhibition and selectivity of bacterial topoisomerases by BMS-284756 and its analogues.

Authors:  L E Lawrence; P Wu; L Fan; K E Gouveia; A Card; M Casperson; K Denbleyker; J F Barrett
Journal:  J Antimicrob Chemother       Date:  2001-08       Impact factor: 5.790

Review 9.  DNA gyrase: structure and function.

Authors:  R J Reece; A Maxwell
Journal:  Crit Rev Biochem Mol Biol       Date:  1991       Impact factor: 8.250

10.  Inhibition by quinolones of DNA gyrase from Staphylococcus aureus.

Authors:  M Tanaka; K Sato; Y Kimura; I Hayakawa; Y Osada; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  1991-07       Impact factor: 5.191
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  2 in total

1.  Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone.

Authors:  Dilek Ince; Xiamei Zhang; L Christine Silver; David C Hooper
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

2.  A New Calcium(II)-Based Substitute for Enrofloxacin with Improved Medicinal Potential.

Authors:  Hou-Tian Yan; Rui-Xue Liu; Qi-Zhen Yang; Yan-Cheng Liu; Hong-Chang Li; Rui-Feng Guo; Lin-Hua Wu; Li-Min Liu; Hong Liang
Journal:  Pharmaceutics       Date:  2022-01-21       Impact factor: 6.321
  2 in total

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