Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Opioid antagonists in the treatment of alcohol dependence.

Literature DB >> 11707162

Opioid antagonists in the treatment of alcohol dependence.

Abstract

This article reviews the use of opioid antagonists in the pharmacologic treatment of alcohol dependence. The rationale for using the opioid antagonists naltrexone and nalmefene to prevent relapse in alcohol-dependent subjects is discussed by reviewing past and current clinical trials. The role of psychotherapies, particularly coping skills therapy, in combination with opioid antagonists is highlighted in the presentations of the clinical data. Finally, future research directions for opioid antagonists are discussed.

Entities: Chemical

Mesh：

Substances：

Year: 2001 PMID： 11707162 DOI： 10.1007/s11920-001-0042-x

Source DB: PubMed Journal: Curr Psychiatry Rep ISSN： 1523-3812 Impact factor: 8.081

40 in total

1. A multicentre, randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence or abuse.

Authors: J Chick; R Anton; K Checinski; R Croop; D C Drummond; R Farmer; D Labriola; J Marshall; J Moncrieff; M Y Morgan; T Peters; B Ritson
Journal: Alcohol Alcohol Date: 2000 Nov-Dec Impact factor: 2.826

Opioid antagonists in the treatment of alcohol dependence.

1. A multicentre, randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence or abuse.

2. Naltrexone pharmacology, pharmacokinetics, and metabolism: current status.

3. Targeted naltrexone treatment of early problem drinkers.

4. Naltrexone, an antagonist for the treatment of heroin dependence. Effects in man.

5. A double-blind, placebo-controlled study of oral nalmefene for alcohol dependence.

6. Serum 6-beta-naltrexol levels are related to alcohol responses in heavy drinkers.

7. High-dose naltrexone therapy and dietary counseling for obesity.

8. Alcohol interactions with brain opiate receptors.

9. Naltrexone-induced alterations in human ethanol intoxication.

10. Tests of opioid deficiency hypotheses of alcoholism.

Review 1. Bidirectional translational research: Progress in understanding addictive diseases.