Literature DB >> 11706972

Case-Control study of the extended tau gene haplotype in Parkinson's disease.

D M Maraganore1, D G Hernandez, A B Singleton, M J Farrer, S K McDonnell, M L Hutton, J A Hardy, W A Rocca.   

Abstract

We investigated the association of Parkinson's disease with tau gene haplotypes. In a sample of 319 unrelated Parkinson's disease patients and 196 control subjects, we observed an increased risk of Parkinson's disease for persons with the H1/H1 genotype (odds ratio = 1.5; 95% confidence interval: 0.98-2.23); however, the finding was not statistically significant. The results remained similar after adjusting for the possible misclassification of progressive supranuclear palsy patients as Parkinson's disease, but became statistically significant after restricting the analysis to nondemented subjects.

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Year:  2001        PMID: 11706972     DOI: 10.1002/ana.1228

Source DB:  PubMed          Journal:  Ann Neurol        ISSN: 0364-5134            Impact factor:   10.422


  17 in total

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3.  Common variants in PARK loci and related genes and Parkinson's disease.

Authors:  Sun Ju Chung; Sebastian M Armasu; Joanna M Biernacka; Timothy G Lesnick; David N Rider; Sarah J Lincoln; Alexandra I Ortolaza; Matthew J Farrer; Julie M Cunningham; Walter A Rocca; Demetrius M Maraganore
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4.  Linkage disequilibrium and association of MAPT H1 in Parkinson disease.

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5.  Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.

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6.  Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype.

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Journal:  Hum Genet       Date:  2004-03-04       Impact factor: 4.132

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Authors:  J E Tobin; J C Latourelle; M F Lew; C Klein; O Suchowersky; H A Shill; L I Golbe; M H Mark; J H Growdon; G F Wooten; B A Racette; J S Perlmutter; R Watts; M Guttman; K B Baker; S Goldwurm; G Pezzoli; C Singer; M H Saint-Hilaire; A E Hendricks; S Williamson; M W Nagle; J B Wilk; T Massood; J M Laramie; A L DeStefano; I Litvan; G Nicholson; A Corbett; S Isaacson; D J Burn; P F Chinnery; P P Pramstaller; S Sherman; J Al-hinti; E Drasby; M Nance; A T Moller; K Ostergaard; R Roxburgh; B Snow; J T Slevin; F Cambi; J F Gusella; R H Myers
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9.  Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease.

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Journal:  Ann Neurol       Date:  2007-08       Impact factor: 10.422

10.  Role of the H1 haplotype of microtubule-associated protein tau (MAPT) gene in Greek patients with Parkinson's disease.

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Journal:  BMC Neurol       Date:  2009-06-28       Impact factor: 2.474

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