OBJECTIVE: To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP). BACKGROUND: LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases, especially AD. METHOD: The authors evaluated the brains of 72 consecutive cases of pathologically confirmed PSP and 98 normal controls, ranging in age from 60 to 100 years, with immunohistochemistry for alpha-synuclein. RESULTS: LB and Lewy neurites were found in 13 cases of PSP, with the most numerous LB and Lewy neurites in the basal forebrain and amygdala; most cases also had LB in the substantia nigra. The frequency of LB in the substantia nigra (12%) was comparable to the frequency of LB in controls (9%). CONCLUSIONS: In contrast to increased frequency of LB in AD, there is no apparent interaction between LB and the tau pathology in PSP.
OBJECTIVE: To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP). BACKGROUND: LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases, especially AD. METHOD: The authors evaluated the brains of 72 consecutive cases of pathologically confirmed PSP and 98 normal controls, ranging in age from 60 to 100 years, with immunohistochemistry for alpha-synuclein. RESULTS: LB and Lewy neurites were found in 13 cases of PSP, with the most numerous LB and Lewy neurites in the basal forebrain and amygdala; most cases also had LB in the substantia nigra. The frequency of LB in the substantia nigra (12%) was comparable to the frequency of LB in controls (9%). CONCLUSIONS: In contrast to increased frequency of LB in AD, there is no apparent interaction between LB and the tau pathology in PSP.
Authors: Heather B Rigby; Brittany N Dugger; Joseph G Hentz; Charles H Adler; Thomas G Beach; Holly A Shill; Erika Driver-Dunckley; Marwan N Sabbagh; Lucia I Sue; John N Caviness Journal: Mov Disord Clin Pract Date: 2014-10-29
Authors: María Elena Erro Aguirre; María Victoria Zelaya; Javier Sánchez Ruiz de Gordoa; María Teresa Tuñón; José Luis Lanciego Journal: Front Neuroanat Date: 2015-03-11 Impact factor: 3.856